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本文引用的文献

1
Identification of Essential Residues for Ciprofloxacin Resistance of Ciprofloxacin-Modifying Enzyme (CrpP) of pUM505.鉴定 pUM505 中环丙沙星修饰酶（CrpP）导致环丙沙星耐药的必需残基。
Microbiology (Reading). 2020 Apr;166(4):367-374. doi: 10.1099/mic.0.000889. Epub 2020 Jan 28.
2
CrpP, a passenger or a hidden stowaway in the Pseudomonas aeruginosa genome?CrpP是铜绿假单胞菌基因组中的过客还是隐藏的偷渡者？
J Antimicrob Chemother. 2019 Nov 1;74(11):3397-3399. doi: 10.1093/jac/dkz316.
3
ESBLs and resistance to ceftazidime/avibactam and ceftolozane/tazobactam combinations in Escherichia coli and Pseudomonas aeruginosa.大肠埃希菌和铜绿假单胞菌中产 ESBLs 对头孢他啶/阿维巴坦和头孢洛扎/他唑巴坦组合的耐药性。
J Antimicrob Chemother. 2019 Jul 1;74(7):1934-1939. doi: 10.1093/jac/dkz149.
4
Investigation of six plasmid-mediated quinolone resistance genes among clinical isolates of pseudomonas: a genotypic study in Saudi Arabia.沙特阿拉伯假单胞菌临床分离株中六种质粒介导喹诺酮耐药基因的调查：一项基因型研究
Infect Drug Resist. 2019 Apr 29;12:915-923. doi: 10.2147/IDR.S203288. eCollection 2019.
5
Prevalence of the crpP gene conferring decreased ciprofloxacin susceptibility in enterobacterial clinical isolates from Mexican hospitals.墨西哥医院肠道细菌临床分离株中携带导致环丙沙星敏感性降低的crpP基因的流行情况。
J Antimicrob Chemother. 2019 May 1;74(5):1253-1259. doi: 10.1093/jac/dky562.
6
Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: new approaches to an old problem.铜绿假单胞菌中环丙沙星耐药机制：老问题的新方法。
J Med Microbiol. 2019 Jan;68(1):1-10. doi: 10.1099/jmm.0.000873.
7
Multiple mechanisms contributing to ciprofloxacin resistance among Gram negative bacteria causing infections to cancer patients.导致癌症患者感染的革兰氏阴性菌对环丙沙星产生耐药性的多种机制。
Sci Rep. 2018 Aug 16;8(1):12268. doi: 10.1038/s41598-018-30756-4.
8
A plasmid-encoded mobile genetic element from Pseudomonas aeruginosa that confers heavy metal resistance and virulence.一种来自铜绿假单胞菌的质粒编码可移动遗传元件，其赋予重金属抗性和毒力。
Plasmid. 2018 Jun;98:15-21. doi: 10.1016/j.plasmid.2018.07.003. Epub 2018 Jul 29.
9
CrpP Is a Novel Ciprofloxacin-Modifying Enzyme Encoded by the Pseudomonas aeruginosa pUM505 Plasmid.铜绿假单胞菌 pUM505 质粒编码的 CRPp 是一种新型环丙沙星修饰酶。
Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.02629-17. Print 2018 Jun.
10
Plasmid pUM505 encodes a Toxin-Antitoxin system conferring plasmid stability and increased Pseudomonas aeruginosa virulence.质粒 pUM505 编码了一种毒素-抗毒素系统，赋予了质粒稳定性和增强的铜绿假单胞菌毒力。
Microb Pathog. 2017 Nov;112:259-268. doi: 10.1016/j.micpath.2017.09.060. Epub 2017 Sep 29.

欧洲铜绿假单胞菌临床分离株中与致病性基因组岛相关的CrpP样氟喹诺酮修饰酶

Pathogenicity Genomic Island-Associated CrpP-Like Fluoroquinolone-Modifying Enzymes among Pseudomonas aeruginosa Clinical Isolates in Europe.

作者信息

Ortiz de la Rosa José Manuel, Nordmann Patrice, Poirel Laurent

机构信息

Medical and Molecular Microbiology, Department of Medicine, Faculty of Science and Medicine, Fribourg, University of Fribourg, Switzerland.

INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland.

出版信息

Antimicrob Agents Chemother. 2020 Jun 23;64(7). doi: 10.1128/AAC.00489-20.

DOI:10.1128/AAC.00489-20
PMID:32340994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7318011/
Abstract

Many transferable quinolone resistance mechanisms have been identified in Gram-negative bacteria. The plasmid-encoded 65-amino-acid-long ciprofloxacin-modifying enzyme CrpP was recently identified in isolates. We analyzed a collection of 100 clonally unrelated and multidrug-resistant clinical isolates, among which 46 were positive for -like genes, encoding five CrpP variants conferring variable levels of reduced susceptibility to fluoroquinolones. These -like genes were chromosomally located as part of pathogenicity genomic islands.

摘要

在革兰氏阴性菌中已鉴定出许多可转移的喹诺酮耐药机制。最近在分离株中鉴定出了质粒编码的65个氨基酸长的环丙沙星修饰酶CrpP。我们分析了100株克隆无关且耐多药的临床分离株，其中46株的类基因呈阳性，这些类基因编码五种CrpP变体，对氟喹诺酮类药物的敏感性降低程度各不相同。这些类基因位于染色体上，是致病性基因组岛的一部分。