Emergence of Clinical Isolate Guangzhou-PaeC79 Carrying , , and in Guangzhou of China.

As a potential "Superbug," remains the leading concern in antimicrobial resistance. In this study, the emergence of clinical isolate was found to carry and on the chromosome and on a plasmid. A clinical strain Guangzhou-PaeC79 with an extensively drug-resistant phenotype was isolated, which was resistant to all classes of clinical commonly used antibiotics. It contains one chromosomal DNA and one plasmid, with seven acquired antimicrobial resistance genes identified on the chromosome, including carbapenem resistance gene and fluoroquinolone resistance gene , and carbapenem resistance gene located on an IncP-6-type plasmid pPAEC79 carrying a Tn-like element. Carriage of any two of the resistance genes has never been previously reported, and simultaneous carriage of three and may explain the bacterial phenotype as high-level resistance to imipenem and meropenem (≥16 μg/mL) and resistance to ciprofloxacin and levofloxacin.