Department of Neurology, Sheba Medical Center, Ramat Gan, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Neuroimmunol. 2020 Jul 15;344:577248. doi: 10.1016/j.jneuroim.2020.577248. Epub 2020 Apr 22.
Neuroaxonal injury and loss result in the release of cytoskeleton components, including neurofilaments, into the cerebrospinal fluid and peripheral blood. Once released, neurofilaments are highly immunogenic, inducing a specific antibody response. Anti-neurofilament antibody levels correlate with the progression of diverse neurological diseases; however, their role both in the pathogenesis of disease and as a tool for monitoring disease progression is not well understood. This study reviews the current literature on anti-neurofilament antibodies. We suggest the testing of anti-neurofilament antibodies be further developed for diagnosis and targeted for treatment.
神经轴突损伤和丢失导致细胞骨架成分（包括神经丝）释放到脑脊液和外周血中。一旦释放，神经丝就具有高度的免疫原性，诱导出特异性抗体反应。抗神经丝抗体水平与多种神经疾病的进展相关；然而，它们在疾病发病机制中的作用以及作为监测疾病进展的工具尚不完全清楚。本研究综述了抗神经丝抗体的现有文献。我们建议进一步开发抗神经丝抗体的检测方法，用于诊断和靶向治疗。
