Lee Chung-Shien, Devoe Craig E, Zhu Xinhua, Fishbein Joanna Stein, Seetharamu Nagashree
St. John's University, College of Pharmacy & Health Sciences, Department of Clinical Health Professions, Queens, NY 11439, USA.
Division of Medical Oncology & Hematology, Northwell Health Cancer Institute, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY 11042, USA.
Lung Cancer Manag. 2020 Apr 24;9(2):LMT31. doi: 10.2217/lmt-2020-0008.
Checkpoint inhibitors are integral to non-small-cell lung cancer treatment. Existing data suggests that nutritional status may play a role in antitumor immunity.
MATERIALS & METHODS: This retrospective study of 106 non-small-cell lung cancer patients who started checkpoint inhibitors between 2014 and 2017 at our institution assessed relationship of nutritional parameters to overall survival (OS) and progression-free survival.
Mean age was 68.7 ± 9.2 years and 59.4% patients were male. On multivariate analysis for OS, hypoalbuminemia and significant weight loss were prognostic at p-values of 0.0005 and 0.0052, respectively. We noted a parabolic association between age and OS (p = 0.026, 0.0025).
In our study, some malnutrition parameters were associated with decreased OS. U-shape relationship between age and OS noted here warrants further evaluation.
检查点抑制剂是非小细胞肺癌治疗的重要组成部分。现有数据表明，营养状况可能在抗肿瘤免疫中发挥作用。
这项回顾性研究对2014年至2017年间在我们机构开始使用检查点抑制剂的106例非小细胞肺癌患者进行了评估，分析营养参数与总生存期（OS）和无进展生存期之间的关系。
平均年龄为68.7±9.2岁，59.4%的患者为男性。在对总生存期的多因素分析中，低白蛋白血症和显著体重减轻具有预后意义，p值分别为0.0005和0.0052。我们注意到年龄与总生存期之间呈抛物线关系（p = 0.026，0.0025）。
在我们的研究中，一些营养不良参数与总生存期降低有关。此处所指出的年龄与总生存期之间的U形关系值得进一步评估。
