干扰素诱导跨膜蛋白 3 基因变异 rs12252-C 与 2019 年冠状病毒病疾病严重程度相关。
Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019.
机构信息
Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, United Kingdom.
出版信息
J Infect Dis. 2020 Jun 16;222(1):34-37. doi: 10.1093/infdis/jiaa224.
Abstract
A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.
摘要
在当前全球 2019 年冠状病毒病（COVID-19）爆发中，一个尚未得到解答的主要问题是为什么只有少数感染者会发展为重症疾病。在当前的文章中，我们报告称干扰素诱导跨膜蛋白 3（IFITM3）基因中的 rs12252 等位基因 C 纯合与年龄相关的更严重疾病有关。这支持 IFITM3 在疾病发病机制中的作用以及为高危个体提供早期靶向干预的机会。
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