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干扰素诱导跨膜蛋白 3 基因 rs12252 多态性对 COVID-19 死亡率的影响。

Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality.

机构信息

Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran.

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.

出版信息

Cytokine. 2022 Sep;157:155957. doi: 10.1016/j.cyto.2022.155957. Epub 2022 Jul 2.

DOI:10.1016/j.cyto.2022.155957
PMID:35792282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9250290/
Abstract

BACKGROUND AND AIMS

Interferon-induced transmembrane protein 3 (IFITM3) plays a critical role in the adaptive and innate immune response by preventing membrane hemifusion between the host and viral cell cytoplasm. This study aimed to evaluate whether IFITM3 rs12252 polymorphism is related to an increased mortality rate of coronavirus disease 2019 (COVID-19).

METHODS

The IFITM3 rs12252 polymorphism was genotyped using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) in 548 dead and 630 improved patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

RESULTS

In the present study, the minor allele frequency of IFITM3 rs12252 (C) was significantly more frequent in dead patients than in improved cases. The results of the multivariate logistic regression analysis indicated that the lower lipid profiles, PCR Ct value, 25-hydroxyvitamin D, and uric acid and higher levels of erythrocyte sedimentation rate (ESR), liver enzymes, and creatinine, and IFITM3 rs12252 CC genotypes were related to the COVID-19 infection mortality.

CONCLUSIONS

In summary, our findings suggested a possible link between the mortality of COVID-19 infection, the CC genotypes of IFITM3 rs12252, and clinical parameters. Further investigations are required worldwide to prove the link relationship of COVID-19 mortality with host genetic factors.

摘要

背景与目的

干扰素诱导跨膜蛋白 3（IFITM3）通过阻止宿主与病毒细胞质之间的膜半融合，在适应性和先天免疫反应中发挥关键作用。本研究旨在评估 IFITM3 rs12252 多态性是否与 2019 年冠状病毒病（COVID-19）死亡率增加有关。

方法

使用扩增受阻突变系统-聚合酶链反应（ARMS-PCR）对 548 名死亡和 630 名改善的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）阳性患者的 IFITM3 rs12252 多态性进行基因分型。

结果

在本研究中，IFITM3 rs12252（C）的次要等位基因频率在死亡患者中明显高于改善病例。多变量逻辑回归分析的结果表明，较低的血脂谱、PCR Ct 值、25-羟维生素 D、尿酸水平以及较高的红细胞沉降率（ESR）、肝酶和肌酐水平，以及 IFITM3 rs12252 CC 基因型与 COVID-19 感染死亡率有关。

结论

综上所述，我们的研究结果表明，COVID-19 感染死亡率、IFITM3 rs12252 的 CC 基因型与临床参数之间可能存在关联。需要在全球范围内进行进一步的研究，以证明 COVID-19 死亡率与宿主遗传因素之间的关联关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/9250290/37f2ce077ca7/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/9250290/37f2ce077ca7/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/9250290/37f2ce077ca7/gr1_lrg.jpg

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