Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, People's Republic of China.
Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway Avenue, Austin, TX, 78712, United States; McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, United States.
Curr Opin Chem Biol. 2020 Dec;59:15-22. doi: 10.1016/j.cbpa.2020.03.004. Epub 2020 Apr 27.
Biotechnology offers a green alternative for the production of fuels and chemicals using microbes. Although traditional model hosts such as Escherichia coli and Saccharomyces cerevisiae have been widely studied and used, they may not be the best hosts for industrial application. In this review, we explore recent advances in the use of nonconventional hosts for the production of a variety of fuel, cosmetics, perfumes, food, and pharmaceuticals. Specifically, we highlight twenty-seven popular molecules with a special focus on recent progress and metabolic engineering strategies to enable improved production of fuels and chemicals. These examples demonstrate the promise of nonconventional host engineering.
生物技术为使用微生物生产燃料和化学品提供了一种绿色替代方案。尽管传统的模式宿主，如大肠杆菌和酿酒酵母，已经得到了广泛的研究和应用，但它们可能不是工业应用的最佳宿主。在这篇综述中，我们探讨了使用非传统宿主生产各种燃料、化妆品、香水、食品和药品的最新进展。具体来说，我们重点介绍了二十七个流行的分子，特别关注最近的进展和代谢工程策略，以实现燃料和化学品生产的改善。这些例子展示了非传统宿主工程的潜力。
