Mirzadeh Mahdieh, Nikparvar Marzieh, Rafati Shideh, Kheirandish Masoumeh, Azarbad Abnoos, Sheybani-Arani MohammadHosein, Khajavi-Mayvan Fatemeh, Morovatshoar Reza
Clinical Research Development Center of Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Egypt Heart J. 2024 May 28;76(1):65. doi: 10.1186/s43044-024-00497-z.
Coronary artery disease (CAD) is an atherosclerotic disease of an inflammatory nature. Previous studies examining the relationship between triglycerides and high-density lipoprotein cholesterol have highlighted the importance of plasma atherogenic index (AIP) as an important predictor of coronary heart disease. However, due to the lack of adequate information on this topic, this study aimed to investigate the relationship between AIP and coronary heart disease risk.
This study included 2,226 women and 1,690 men aged 35-70 years who participated in the Bandar Kong Cohort study and met the eligibility criteria. The data was collected using a checklist and questionnaires, which were designed by experienced individuals. After participants completed a registration form and gave informed consent, face-to-face interviews were conducted by trained experts. The validity and reliability of the questionnaire had been verified by the national cohort team prior to its use. The Ethics Committee of Hormozgan University of Medical Sciences (IR.HUMS.REC.1400.171) approved the study. Data from the initial cohort survey using SPSS software version 25, were analyzed to include several factors, including age, sex, smoking status, body mass index (BMI), physical activity level, socioeconomic status, AIP, systolic blood pressure, and diastolic blood pressure. The prevalence of coronary heart disease was found to be 7.5% higher in people with a BMI of 25 or higher. Also, Individuals with low physical activity had a higher prevalence. Individuals with CAD had significantly higher mean values for the AIP, age, systolic blood pressure, and diastolic blood pressure (0.46, 57.50, 128.43, and 81.10, respectively) compared to those without CAD. Furthermore, patients with CAD had lower years of education (2649.45 and 3.59) than individuals without CAD (P < 0.05). Importantly, our findings showed that AIP increased the odds ratio of coronary heart disease by 1.86 as an independent risk factor.
Based on our investigation, the AIP is a valuable and independent predictive risk factor for coronary artery disease. This index can be utilized effectively due to its accessibility and affordability, making it a promising tool for risk assessment in clinical settings.
冠状动脉疾病（CAD）是一种具有炎症性质的动脉粥样硬化疾病。以往研究甘油三酯与高密度脂蛋白胆固醇之间的关系时，强调了血浆致动脉粥样硬化指数（AIP）作为冠心病重要预测指标的重要性。然而，由于关于该主题的信息不足，本研究旨在探讨AIP与冠心病风险之间的关系。
本研究纳入了2226名年龄在35至70岁之间的女性和1690名男性，他们参与了班达尔孔队列研究并符合入选标准。数据通过由经验丰富的人员设计的清单和问卷收集。参与者填写登记表并签署知情同意书后，由经过培训的专家进行面对面访谈。问卷的有效性和可靠性在使用前已由国家队列团队验证。霍尔木兹甘医科大学伦理委员会（IR.HUMS.REC.1400.171）批准了该研究。使用SPSS软件25版对初始队列调查数据进行分析，纳入了几个因素，包括年龄、性别、吸烟状况、体重指数（BMI）、身体活动水平、社会经济状况、AIP、收缩压和舒张压。发现BMI为25或更高的人群中冠心病患病率高7.5%。此外，身体活动水平低的个体患病率更高。与无CAD的个体相比，CAD患者的AIP、年龄、收缩压和舒张压的平均值显著更高（分别为0.46、57.50、128.43和81.10）。此外，CAD患者的受教育年限（2649.45和3.59）低于无CAD的个体（P<0.05）。重要的是，我们的研究结果表明，AIP作为独立危险因素使冠心病的比值比增加1.86。
基于我们的调查，AIP是冠状动脉疾病的一个有价值的独立预测危险因素。由于其可及性和可承受性，该指标可有效利用，使其成为临床环境中风险评估的一个有前景的工具。
