Wang Siyu, Yan Fei, Ren Ping, Li Yi, Wu Qiong, Fang Xuedong, Chen Fangfang, Wang Ce
Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, PR China.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, PR China.
Int J Biol Macromol. 2020 Apr 27;158:9-17. doi: 10.1016/j.ijbiomac.2020.04.116.
Developing wound dressing that inhibits bacterial infection for treating complex wound healing processes has been a research hotspot. Here, we report the fabrication of Cu-MOFs (HKUST-1) incorporated electrospun chitosan/polyvinyl alcohol (HKUST-1/chitosan/PVA) fibers through the blending electrospinning for wound therapy. HKUST-1/chitosan/PVA fibers displayed satisfying physical properties, such as mechanical property, water uptake, water vapor transmission rate, etc. Cytotoxicity test indicated that HKUST-1/chitosan/PVA fibers were biocompatible and could support cell adhesion. Due to the HKUST-1 incorporation, HKUST-1/chitosan/PVA fibers exhibited the good antibacterial activity against Escherichia coli and Staphylococcus aureus with 99% antibacterial efficiency. Furthermore, in animal studies, compared with commercial chitosan dressings and chitosan/PVA fibers, HKUST-1/chitosan/PVA fibers were more efficient to heal the wound with less inflammation. In summary, the HKUST-1/chitosan/PVA fibers with good physicochemical property, biocompatibility and antibacterial property is an excellent wound dressing for full-thickness skin repair.
开发能够抑制细菌感染以治疗复杂伤口愈合过程的伤口敷料一直是研究热点。在此，我们报道了通过共混静电纺丝制备用于伤口治疗的铜基金属有机框架材料（HKUST-1）复合静电纺丝壳聚糖/聚乙烯醇（HKUST-1/壳聚糖/PVA）纤维。HKUST-1/壳聚糖/PVA纤维表现出令人满意的物理性能，如机械性能、吸水性、水蒸气透过率等。细胞毒性测试表明HKUST-1/壳聚糖/PVA纤维具有生物相容性且能支持细胞黏附。由于掺入了HKUST-1，HKUST-1/壳聚糖/PVA纤维对大肠杆菌和金黄色葡萄球菌表现出良好的抗菌活性，抗菌效率达99%。此外，在动物研究中，与市售壳聚糖敷料和壳聚糖/PVA纤维相比，HKUST-1/壳聚糖/PVA纤维能更有效地愈合伤口且炎症更少。总之，具有良好物理化学性质、生物相容性和抗菌性能的HKUST-1/壳聚糖/PVA纤维是用于全层皮肤修复的优异伤口敷料。
