Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK.
Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Curr Opin Immunol. 2020 Jun;64:42-49. doi: 10.1016/j.coi.2020.03.008. Epub 2020 Apr 27.
The serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities through FALCs makes them unique niches for the clearance of fluid phase contaminants and initiation of locally protective immune responses during infection and inflammation. Development, and activation of FALCs both at homeostasis and following inflammation are co-ordinated by the close interaction of mesothelial and fibroblastic stromal cell populations with immune cells. In this review we discuss recent developments in FALC stromal cell biology and highlight key interactions that occur between FALC stroma and immune cells.
浆膜腔包含专门的脂肪组织，其中有称为脂肪相关淋巴簇（FALC）的小簇免疫细胞。液体从浆膜腔通过 FALC 的持续流动使它们成为清除液相间污染物和在感染和炎症期间引发局部保护性免疫反应的独特小生境。在稳态和炎症后，FALC 的发育和激活均由间皮细胞和纤维母细胞基质细胞群体与免疫细胞的紧密相互作用协调。在这篇综述中，我们讨论了 FALC 基质细胞生物学的最新进展，并强调了 FALC 基质与免疫细胞之间发生的关键相互作用。
