Mani Mishra Pushpendra, Uversky Vladimir N, Nandi Chayan K
School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh 175005, India; BioX Center, Indian Institute of Technology Mandi, Himachal Pradesh 175005, India.
Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, United States; Laboratory of New Methods in Biology, Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Moscow Region 142290, Russia.
Med Hypotheses. 2020 Apr 24;140:109790. doi: 10.1016/j.mehy.2020.109790.
Novel coronavirus (NCoV-19), also known as SARS CoV-2, is a pathogen causing an emerging infection that rapidly increases in incidence and geographic range, is associated with the ever-increasing morbidity and mortality rates, and shows sever economic impact worldwide. The WHO declares the NCoV-19 infection disease (COVID-19) a Public Health Emergency of International Concern on 30 January 2020 and subsequently, on March 11, 2020, declared it a Global Pandemic. Although some people infected with SARS CoV-2 have no symptoms, the spectrum of symptomatic infection ranges from mild to critical, with most COVID-19 infections being not severe. The common mild symptoms include body aches, dry cough, fatigue, low-grade fever, nasal congestion, and sore throat. More severe COVID-19 symptoms are typical of pneumonia, and upon progression, the patient's condition can worsen with severe respiratory and cardiac problems. Currently, there is no drug or vaccine for curing patients. It has been observed that people with challenged immunity are highly prone to SARS CoV-2 infection and least likely to recover. Also, older adults and people of any age with serious underlying medical conditions might be at higher risk for severe forms of COVID-19. We are suggesting here a strategy for the COVID-19 treatment that could be effective in curing the patients in the current scenario when no efficient medicine or Vaccine is currently available, and Clinicians solely depend upon the performing trials with drugs with known antiviral activities. Our proposed strategy is based on the compilation of published scientific research and concepts. The different published research indicates the success of a similar strategy in different physiological conditions, and such a strategy is widely studied at the cellular level and in animal models.
新型冠状病毒（NCoV-19），也被称为严重急性呼吸综合征冠状病毒2（SARS-CoV-2），是一种引发新出现感染的病原体，其发病率和地理范围迅速增加，与不断上升的发病率和死亡率相关，并在全球范围内显示出严重的经济影响。世界卫生组织于2020年1月30日宣布NCoV-19感染疾病（COVID-19）为国际关注的突发公共卫生事件，随后在2020年3月11日宣布其为全球大流行。虽然一些感染SARS-CoV-2的人没有症状，但有症状感染的范围从轻度到重症，大多数COVID-19感染并不严重。常见的轻度症状包括身体疼痛、干咳、疲劳、低热、鼻塞和喉咙痛。更严重的COVID-19症状是典型的肺炎症状，病情进展时，患者的状况会因严重的呼吸和心脏问题而恶化。目前，没有治疗患者的药物或疫苗。据观察，免疫力低下的人极易感染SARS-CoV-2，且康复的可能性最小。此外，老年人和任何年龄有严重基础疾病的人可能患重症COVID-19的风险更高。在此，我们提出一种针对COVID-19的治疗策略，在目前没有有效药物或疫苗且临床医生仅依赖对具有已知抗病毒活性的药物进行试验的情况下，该策略可能对治愈患者有效。我们提出的策略基于已发表的科学研究和概念的汇编。不同的已发表研究表明类似策略在不同生理条件下取得了成功，并且这种策略在细胞水平和动物模型中得到了广泛研究。
