Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato-Cagliari, Italy.
UK National Crystallography Service, School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Molecules. 2020 Apr 28;25(9):2052. doi: 10.3390/molecules25092052.
The reactions of 2,4-bis(4-methoxyphenyl)-1,3-dithio-2,4-diphosphetane-2,4-disulfide (Lawesson's Reagent, LR) with benzylamine (BzNH) and 4-phenylbutylamine (PhBuNH) yield benzylammonium -(4-methoxyphenyl)--benzyl-amidodithiophosphonate (BzNH)(BzNH-adtp) and 4-phenylbutylammonium -(4-methoxyphenyl)--(4-phenylbutyl)-amidodithiophosphonate (PhBuNH)(PhBuNH-adtp). The relevant nickel complexes [Ni(BzNH-adtp)] and [Ni(PhBuNH-adtp)] and the corresponding hydrolysed derivatives (BzNH)[Ni(dtp)] and (PhBuNH)[Ni(dtp)] were prepared and fully characterized. The antimicrobial activity of the aforementioned amidodithiophosphonates against a set of Gram-positive and Gram-negative pathogen bacteria was evaluated, and [Ni(BzNH-adtp)] and [Ni(PhBuNH-adtp)] showed antiproliferative activity towards and strains. density functional theory (DFT) calculations were performed to shed some light on the activity of reported compounds related to their tendency towards P-N bond cleavage.
2,4-双(4-甲氧基苯基)-1,3-二硫-2,4-二磷杂戊二硫醚（劳森试剂，LR）与苄胺（BzNH）和 4-苯基丁胺（PhBuNH）的反应生成苄基铵-(4-甲氧基苯基）-苄基-氨二硫代膦酸盐（BzNH）（BzNH-adtp）和 4-苯基丁基铵-(4-甲氧基苯基）-（4-苯基丁基）-氨二硫代膦酸盐（PhBuNH）（PhBuNH-adtp）。制备并充分表征了相应的镍配合物[Ni（BzNH-adtp）]和[Ni（PhBuNH-adtp）]以及相应的水解衍生物（BzNH）[Ni（dtp）]和（PhBuNH）[Ni（dtp）]。评估了上述氨二硫代膦酸盐对一组革兰氏阳性和革兰氏阴性病原体细菌的抗菌活性，[Ni（BzNH-adtp）]和[Ni（PhBuNH-adtp）]对 和 菌株表现出抗增殖活性。进行了密度泛函理论（DFT）计算，以阐明与它们的 P-N 键断裂倾向相关的报告化合物的活性。
