CNRS UMR 9018, Institut Gustave Roussy, Université Paris-Saclay, 114, rue Édouard Vaillant, 94805 Villejuif, France.
LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, 114, rue Édouard-Vaillant, 94805 Villejuif, France.
Cells. 2020 Apr 28;9(5):1090. doi: 10.3390/cells9051090.
Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication.
哺乳动物雷帕霉素靶蛋白复合物 1（mTORC1）是细胞增殖和存活的主要调节剂，它控制着细胞对不同应激的反应，包括病毒感染。HIV-1 在感染的各个阶段干扰 mTORC1 途径。与此同时，宿主细胞依赖 mTORC1 途径和自噬来对抗病毒复制和传播。在这篇综述中，我们将提供 mTORC1 途径在 HIV-1 生命周期、潜伏期和与 HIV 相关疾病中的最新作用图片。我们还将概述靶向 mTORC1 途径作为 HIV-1 根除的有前途策略的最新趋势。
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