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3
Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.《前列腺癌（2019 年版）》，NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2019 May 1;17(5):479-505. doi: 10.6004/jnccn.2019.0023.
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Current state of interventional radiotherapy (brachytherapy) education in Italy: results of the INTERACTS survey.意大利介入放射治疗（近距离放射治疗）教育的现状：INTERACTS调查结果
J Contemp Brachytherapy. 2019 Feb;11(1):48-53. doi: 10.5114/jcb.2019.83137. Epub 2019 Feb 28.
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Cancer statistics, 2019.癌症统计数据，2019 年。
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J Ultrasound Med. 2019 Jul;38(7):1823-1830. doi: 10.1002/jum.14878. Epub 2018 Dec 17.
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BIT-ART：前列腺癌调强适形放疗、调强放疗和螺旋断层放疗的多中心比较。

BIT-ART: Multicentric Comparison of HDR-brachytherapy, Intensity-modulated Radiotherapy and Tomotherapy for Advanced Radiotherapy in Prostate Cancer.

机构信息

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy

出版信息

In Vivo. 2020 May-Jun;34(3):1297-1305. doi: 10.21873/invivo.11905.

DOI:10.21873/invivo.11905
PMID:32354922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7279807/
Abstract

BACKGROUND/AIM: The aim of the study was to evaluate acute and late genitourinary (GU) and gastrointestinal (GI) toxicity in patients with high- or intermediate-risk prostate cancer.

PATIENTS AND METHODS

We evaluated data of patients from three Radiation Oncology Departments (Rome, Lübeck and Perugia). Patients treated in Rome underwent exclusive intensity-modulated-radiotherapy (IMRT) or IMRT plus high-dose-rate interventional radiotherapy (HDR-IRT). IMRT plus two fractions HDR-IRT was performed in Lübeck, while in Perugia Helical Tomotherapy was performed. The Common Toxicity Criteria for Adverse Event (Version 4.03) scale was used to describe acute and late toxicity.

RESULTS

At a median follow-up of 28 months, all 51 patients were alive and disease-free. Patients treated by HDR-IRT plus VMAT showed only G1-2 genitourinary- gastrointestinal (GU-GI) acute and late toxicity. Univariate analysis showed a lower risk of acute GU toxicity (p=0.048) in IMRT+HDR-IRT.

CONCLUSION

Low grade and less acute GU toxicity was observed in patients undergoing HDR-IRT boost.

摘要

背景/目的：本研究旨在评估高风险或中风险前列腺癌患者的急性和迟发性泌尿生殖系统（GU）和胃肠道（GI）毒性。

患者和方法

我们评估了来自三个放射肿瘤学部门（罗马、吕贝克和佩鲁贾）的患者数据。在罗马接受治疗的患者接受了单纯强度调制放疗（IMRT）或 IMRT 加高剂量率介入放疗（HDR-IRT）。吕贝克采用 IMRT 加两次 HDR-IRT，而佩鲁贾则采用螺旋断层放疗。使用不良事件通用毒性标准（版本 4.03）量表来描述急性和迟发性毒性。

结果

在中位随访 28 个月时，所有 51 例患者均存活且无疾病。接受 HDR-IRT 加 VMAT 治疗的患者仅出现 G1-2 级泌尿生殖-胃肠道（GU-GI）急性和迟发性毒性。单因素分析显示，IMRT+HDR-IRT 组急性 GU 毒性的风险较低（p=0.048）。

结论

接受 HDR-IRT 加量的患者观察到低级别和较少的急性 GU 毒性。