Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences(BUMS), Birjand, Iran.
Environ Sci Pollut Res Int. 2020 Jul;27(20):24799-24814. doi: 10.1007/s11356-020-09045-z. Epub 2020 May 1.
Organophosphorus pesticides (OPs) are widely used for controlling pests worldwide. The inhibitory effects of these pesticides on acetylcholinesterase lead to neurotoxic damages. The oxidative stress is responsible for several neurological diseases, including Parkinson's disease, seizure, depression, and Alzheimer's disease. Strong evidence suggests that dysfunction of mitochondria and oxidative stress are involved in neurological diseases. OPs can disturb the function of mitochondria by inducing oxidative stress. In the present study, we tried to highlight the role of dysfunction of mitochondria and the induction of oxidative stress in the neurotoxicity induced by OPs. Additionally, the amelioration of OP-induced oxidative damage and mitochondrial dysfunctional through the chemical and natural antioxidants have been discussed.
有机磷农药（OPs）在世界范围内被广泛用于防治害虫。这些农药对乙酰胆碱酯酶的抑制作用导致神经毒性损伤。氧化应激是导致几种神经疾病的原因，包括帕金森病、癫痫、抑郁和阿尔茨海默病。有强有力的证据表明，线粒体功能障碍和氧化应激与神经疾病有关。OPs 通过诱导氧化应激干扰线粒体的功能。在本研究中，我们试图强调线粒体功能障碍和氧化应激诱导在 OPs 诱导的神经毒性中的作用。此外，还讨论了通过化学和天然抗氧化剂改善 OPs 诱导的氧化损伤和线粒体功能障碍。
