Boston University School of Medicine, Boston, Massachusetts.
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
J Am Acad Dermatol. 2020 Aug;83(2):343-363. doi: 10.1016/j.jaad.2020.03.123. Epub 2020 Apr 28.
The cutaneous manifestations of lupus, especially chronic cutaneous lupus erythematosus, are a source of significant morbidity and can negatively impact patient quality of life. While the active inflammatory component of the disease may be adequately treated, patients are frequently left with residual skin damage and disfiguring aesthetic deficits. Dermatologists lack guidelines regarding the use and safety of various reconstructive and cosmetic interventions in this patient population. Laser treatments are largely avoided in the lupus population because of the possible photodamaging effects of ultraviolet and visible light. Similarly, given the autoimmune nature of this disease, some physicians avoid injectable treatment and grafts because of the concern for disease reactivation via antigenic stimulation. In the second article in this continuing medical education series we compile available data on this topic with the goal of providing evidence-based guidance on the cosmetic treatment of patients with lupus erythematosus with a focus on chronic cutaneous lupus erythematosus.
狼疮的皮肤表现，尤其是慢性皮肤红斑狼疮，是发病率高的原因之一，会对患者的生活质量产生负面影响。虽然疾病的活动炎症成分可能得到充分治疗，但患者经常会留下残余的皮肤损伤和毁容性的美容缺陷。皮肤科医生缺乏关于在这类患者人群中使用各种重建和美容干预措施的安全性的指南。由于紫外线和可见光可能产生光损伤作用，激光治疗在狼疮患者中基本被避免。同样，由于这种疾病的自身免疫性质，一些医生避免使用注射治疗和移植物，因为担心通过抗原刺激使疾病重新激活。在这个继续教育系列的第二篇文章中，我们汇集了关于这个主题的现有数据，旨在为红斑狼疮患者的美容治疗提供循证指导，重点关注慢性皮肤红斑狼疮。
