McIlvaine W B, Chang J H, Jones M
Department of Anesthesia, Kempe Center for Pediatric Research, Children's Hospital, Denver, CO.
J Pediatr Surg. 1988 Dec;23(12):1184-7. doi: 10.1016/s0022-3468(88)80339-7.
Twenty-four patients having undergone thoracotomies and subcostal incisions were treated for 24 hours with intrapleural bupivacaine with epinephrine. Vital signs, pain scores, and serum bupivacaine levels were recorded. No patient required narcotic medications and all patients obtained adequate analgesia. There were no complications of the technique or toxicity of the drug. Further studies need to be performed to extend the duration of use, to determine pharmacokinetics, and to compare with other techniques.
24例行开胸手术和肋下切口手术的患者接受了胸膜腔内布比卡因加肾上腺素治疗24小时。记录生命体征、疼痛评分和血清布比卡因水平。无患者需要使用麻醉药物，所有患者均获得了充分的镇痛效果。该技术及药物均无并发症或毒性反应。需要进一步开展研究以延长使用时间、确定药代动力学并与其他技术进行比较。
