Ankara University Technopolis, Bioretina, Ankara, Turkey.
Neorama Ofis 55-56 Yaşam Cad, No 13/A Beştepe /Yenimahalle, Ankara, Turkey.
Lasers Med Sci. 2021 Mar;36(2):317-323. doi: 10.1007/s10103-020-03031-0. Epub 2020 May 4.
To investigate the effects of subliminal micropulse yellow laser application on the central macular thickness and best-corrected visual acuity in cystoid macular edema secondary to retinitis pigmentosa patients. This prospective open-label clinical trial, conducted between January 2018 and October 2019, included 32 eyes of 29 patients who had cystoid macular edema secondary to retinitis pigmentosa. Patients were treated by subliminal micropulse yellow laser for one session. Central macular thickness and best-corrected visual acuity changes were investigated just before the treatment and 1 year later after the one session of the treatment. The mean central macular thickness was 651.3 μm before the treatment and 247.7 μm at 12 months after the treatment. The decrease in mean central macular thickness was statistically significant (p = 0.01). Median best-corrected visual acuity was 66.8 ETDRS letters before the treatment and 70.0 letters at 12 months after the treatment. The increase in best-corrected visual acuity was not statistically significant (p = 0.18). Eighty-six percent of the patients stated that the quality of central vision increased and that color vision, contrast sensitivity, and distortion improved. We did not encounter any serious adverse events related to the application of subliminal micropulse yellow laser. The subliminal micropulse yellow laser seems to be a therapeutic, effective, and safe option for the treatment of non-inflammatory and resistant cystoid macular edema secondary to retinitis pigmentosa patients. ClinicalTrials.gov ID: NCT04234438, January 17, 2020.
探讨亚阈微脉冲黄光疗法对色素性视网膜炎相关性囊样黄斑水肿患者的中心黄斑厚度和最佳矫正视力的影响。本前瞻性开放标签临床试验于 2018 年 1 月至 2019 年 10 月进行，纳入了 29 例 32 只眼的色素性视网膜炎相关性囊样黄斑水肿患者。所有患者均接受了一次亚阈微脉冲黄光治疗。治疗前后分别检测中心黄斑厚度和最佳矫正视力。治疗前平均中央黄斑厚度为 651.3μm，治疗后 12 个月时为 247.7μm。平均中央黄斑厚度下降有统计学意义（p=0.01）。治疗前最佳矫正视力中位数为 66.8 ETDRS 字母，治疗后 12 个月为 70.0 字母。最佳矫正视力的提高无统计学意义（p=0.18）。86%的患者表示中心视力质量提高，色觉、对比敏感度和变形改善。我们未发现与亚阈微脉冲黄光应用相关的严重不良事件。亚阈微脉冲黄光似乎是治疗非炎症性和耐药性色素性视网膜炎相关性囊样黄斑水肿的一种有效且安全的选择。临床试验注册号：NCT04234438，2020 年 1 月 17 日。
