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一蟹不如一蟹：果蝇巨噬细胞惊人的异质性。

One too many: the surprising heterogeneity of Drosophila macrophages.

机构信息

Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA, USA.

出版信息

EMBO J. 2020 Jun 17;39(12):e105199. doi: 10.15252/embj.2020105199. Epub 2020 May 4.

DOI:10.15252/embj.2020105199
PMID:32363696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7298286/
Abstract

Macrophages are motile cells that roam the extracellular spaces within organs or the body cavity and carry out essential functions in organ development and immunity. New work published in The EMBO Journal adds surprising new insights into the heterogeneity of Drosophila macrophages revealing many similarities to their vertebrate counterparts.

摘要

巨噬细胞是游走细胞，它们在器官或体腔的细胞外空间中漫游，并在器官发育和免疫中发挥重要作用。发表在《欧洲分子生物学组织杂志》上的新工作为果蝇巨噬细胞的异质性增添了令人惊讶的新见解，揭示了它们与脊椎动物的许多相似之处。

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本文引用的文献

1
Temporal specificity and heterogeneity of Drosophila immune cells.果蝇免疫细胞的时间特异性和异质性。
EMBO J. 2020 Jun 17;39(12):e104486. doi: 10.15252/embj.2020104486. Epub 2020 Mar 12.
2
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.小鼠大脑小胶质细胞单细胞图谱揭示了由个体发生和组织环境塑造的独特转录特征。
Nat Neurosci. 2019 Jun;22(6):1021-1035. doi: 10.1038/s41593-019-0393-4. Epub 2019 May 6.
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as a Genetic Model for Hematopoiesis.作为造血的遗传模型。
Genetics. 2019 Feb;211(2):367-417. doi: 10.1534/genetics.118.300223.
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The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq.细胞异质性的先天与后天因素：利用单细胞RNA测序解析巨噬细胞基因与环境的相互作用
BMC Genomics. 2017 Jan 7;18(1):53. doi: 10.1186/s12864-016-3445-0.
5
The Heterogeneity of Ly6C Monocytes Controls Their Differentiation into iNOS Macrophages or Monocyte-Derived Dendritic Cells.Ly6C单核细胞的异质性控制其向诱导型一氧化氮合酶巨噬细胞或单核细胞衍生树突状细胞的分化。
Immunity. 2016 Dec 20;45(6):1205-1218. doi: 10.1016/j.immuni.2016.12.001.
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Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.导致二元细胞命运选择的混合谱系状态的单细胞分析。
Nature. 2016 Sep 29;537(7622):698-702. doi: 10.1038/nature19348. Epub 2016 Aug 31.
7
Macrophages and cellular immunity in Drosophila melanogaster.果蝇中的巨噬细胞和细胞免疫。
Semin Immunol. 2015 Dec;27(6):357-68. doi: 10.1016/j.smim.2016.03.010. Epub 2016 Apr 23.
8
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.髓系祖细胞中的转录异质性和谱系决定。
Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013. Epub 2015 Nov 25.
9
The peripheral nervous system supports blood cell homing and survival in the Drosophila larva.外周神经系统支持血细胞归巢和在果蝇幼虫中的存活。
Development. 2011 Dec;138(24):5379-91. doi: 10.1242/dev.067322. Epub 2011 Nov 9.
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