Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Cellular, Development, and Integrative Biology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):e10-e18. doi: 10.1093/gerona/glab314.
While neurodegenerative diseases can strike at any age, the majority of afflicted individuals are diagnosed at older ages. Due to the important impact of age in disease diagnosis, the field of neuroscience could greatly benefit from the many of the theories and ideas from the biology of aging-now commonly referred as geroscience. As discussed in our complementary perspective on the topic, there is often a "silo-ing" between geroscientists who work on understanding the mechanisms underlying aging and neuroscientists who are studying neurodegenerative diseases. While there have been some strong collaborations between the biology of aging and neuroscientists, there is still great potential for enhanced collaborative effort between the 2 fields. To this end, here, we review the state of the geroscience field, discuss how neuroscience could benefit from thinking from a geroscience perspective, and close with a brief discussion on some of the "missing links" between geroscience and neuroscience and how to remedy them. Notably, we have a corresponding, concurrent review from the neuroscience perspective. Our overall goal is to "bridge the gap" between geroscience and neuroscience such that more efficient, reproducible research with translational potential can be conducted.
虽然神经退行性疾病可能在任何年龄发作，但大多数受影响的个体都是在老年时被诊断出来的。由于年龄在疾病诊断中的重要影响，神经科学领域可以从衰老生物学的许多理论和观点中受益匪浅——现在通常被称为衰老科学。正如我们在关于该主题的补充观点中所讨论的，研究衰老机制的衰老科学家和研究神经退行性疾病的神经科学家之间经常存在“筒仓”现象。虽然衰老生物学和神经科学家之间已经有了一些强有力的合作，但这两个领域之间仍有很大的潜力进行更加强化的合作。为此，在这里，我们回顾了衰老科学领域的现状，讨论了神经科学如何从衰老科学的角度受益，并简要讨论了衰老科学和神经科学之间的一些“缺失环节”以及如何弥补这些环节。值得注意的是，我们有一个来自神经科学角度的相应的、同时进行的综述。我们的总体目标是在衰老科学和神经科学之间“架起桥梁”，以便能够进行更高效、更可重复且具有转化潜力的研究。
