用于治疗化脓性汗腺炎的新型治疗方法和靶点。

Novel Therapeutic Approaches and Targets for the Treatment of Hidradenitis Suppurativa.

机构信息

Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy.

Department of Biomedical and Dental Sciences and Morphofunctional Images at the University of Messina, Messina, Italy.

出版信息

Curr Pharm Biotechnol. 2021;22(1):59-72. doi: 10.2174/1389201021666200505100556.

DOI:10.2174/1389201021666200505100556

PMID:32368973

Abstract

BACKGROUND

Hidradenitis Suppurativa (HS) is a chronic, recurrent and disabling inflammatory skin condition, clinically characterized by nodules, bullae, abscesses, fistulae, and draining sinus tracts mainly located in axillae, inguinal folds, inframammary region and buttocks, often leading to pain, scarring, disfigurement and decreased quality of life. Due to its complex nature, with still no completely elucidated etiology and pathogenesis, the management of HS can be challenging. In fact, many patients do not respond to the traditionally available systemic treatments, including antiinflammatories, antibiotics and surgery. Research has provided new insights into the mechanisms of HS, mainly investigating the inflammatory cytokine pathways underlying the disease.

METHODS

We review the current knowledge on newer therapeutic approaches and targets for the treatment of HS, through a PubMed-based literature search.

RESULTS

In this setting, studies on tumor necrosis factor-α, IL-1β, IL-10, and the IL-23/T-helper (Th) 17 and IL12/Th1 axes in immune dysregulation in HS have helped in developing new regimens. Inhibitor of phosphodiesterase 4 and laser treatments have shown clinically meaningful efficacy with good short-term safety and tolerability.

CONCLUSION

Target therapy has revolutionized the treatment of moderate to severe HS, based on the inhibition of specific molecular or cellular targets, directly involved in the pathogenesis of the condition.

摘要

背景

化脓性汗腺炎（HS）是一种慢性、复发性和致残性炎症性皮肤病，临床上表现为结节、水疱、脓肿、瘘管和引流窦道，主要位于腋窝、腹股沟褶皱、乳晕下区域和臀部，常导致疼痛、瘢痕形成、毁容和生活质量下降。由于其性质复杂，病因和发病机制仍不完全清楚，HS 的治疗具有挑战性。事实上，许多患者对传统的全身性治疗（包括抗炎药、抗生素和手术）无反应。研究为 HS 的发病机制提供了新的见解，主要研究了疾病背后的炎症细胞因子途径。