Department of Health Science, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy.
Department of Dermatology, University of Rome Tor Vergata, 00133 Rome, Italy.
Int J Mol Sci. 2020 Nov 10;21(22):8436. doi: 10.3390/ijms21228436.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting areas with a high density of apocrine glands and characterized by subcutaneous nodules that may evolve into fistulas with pus secretion.
The aim of this review is to investigate all current knowledge on cytokine regulation in the pathogenesis of HS. A systematic literature research using the words "cytokine", "interleukin", "pathway", and "hidradenitis suppurativa" was performed in PubMed/Medline and Scopus/Embase databases. A search of the clinicaltrials.gov website for interventional recruiting and completed trials including the term "hidradenitis suppurativa" was also performed up to August 2020. We will discuss the pathogenetic role of various cytokines in HS and potential therapeutic targets for this debilitating disease.
The pathophysiology underlying this complex condition has not been clearly defined. An upregulation of various cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-17, IL-23, and other molecules seems to be related to this inflammatory condition. Various cells, such as lymphocytes T Helper 1 and 17 and keratinocytes seem to be involved in the genesis of this condition.
Several future studies and clinical trials are necessary in order to have new knowledge about HS and to properly treat this complex condition.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，影响大汗腺密度高的区域，其特征为皮下结节，可能发展为带有脓液分泌的瘘管。
本综述旨在研究细胞因子调节在 HS 发病机制中的所有现有知识。在 PubMed/Medline 和 Scopus/Embase 数据库中使用“cytokine”、“interleukin”、“pathway”和“hidradenitis suppurativa”等词进行了系统的文献检索。还在 clinicaltrials.gov 网站上搜索了包括“hidradenitis suppurativa”一词的正在招募的干预性研究和已完成的研究，截至 2020 年 8 月。我们将讨论各种细胞因子在 HS 中的发病机制作用以及这种使人衰弱的疾病的潜在治疗靶点。
这种复杂疾病的病理生理学尚未明确界定。各种细胞因子（如肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1、IL-17、IL-23 等）的上调似乎与这种炎症状态有关。各种细胞，如辅助性 T 细胞 1 和 17 以及角质形成细胞，似乎参与了这种疾病的发生。
为了更好地治疗这种复杂的疾病，需要进行更多的未来研究和临床试验，以便更好地了解 HS。
