Normandie Univ, UNICAEN, Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), 14000 Caen, France.
WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
J Org Chem. 2020 Jul 2;85(13):8300-8310. doi: 10.1021/acs.joc.0c00644. Epub 2020 May 13.
Organic compounds bearing radioisotopes of iodine are widely used for biological research, diagnostic imaging, and radiotherapy. Early reported synthetic methods for the incorporation of radioiodine have generally involved high temperature reactions or strongly oxidizing conditions. To overcome these limitations and to cope with the demand for novel radioiodinated probes, there has been a surge in the development of new synthetic methodology for radioiodination. This synopsis describes the key transformations developed recently.
带有放射性碘同位素的有机化合物被广泛用于生物研究、诊断成像和放射治疗。早期报道的放射性碘掺入的合成方法通常涉及高温反应或强氧化条件。为了克服这些限制并满足对新型放射性碘探针的需求，放射性碘标记的新合成方法学得到了迅速发展。本文综述描述了最近开发的关键转化。
