Lazarev Vladimir F, Guzhova Irina V, Margulis Boris A
Institute of Cytology of the Russian Academy of Sciences, St. Petersburg 194064, Russia.
Pharmaceutics. 2020 May 2;12(5):416. doi: 10.3390/pharmaceutics12050416.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in pathologic processes needs further elucidation. Depending on the cell context, GAPDH may bind a number of physiologically important proteins, control their function and correspondingly affect the cell's fate. These interprotein interactions and post-translational modifications of GAPDH mediate its cytotoxic or cytoprotective functions in the manner of a Janus-like molecule. In this review, we discuss the functional features of the enzyme in cellular physiology and its possible involvement in human pathologies. In the last part of the article, we describe drugs that can be employed to modulate this enzyme's function in some pathologic states.
甘油醛-3-磷酸脱氢酶（GAPDH）是一种糖酵解酶，其在细胞代谢和体内平衡中的作用已得到明确界定，而其在病理过程中的功能尚需进一步阐明。根据细胞环境的不同，GAPDH可能会结合多种具有重要生理意义的蛋白质，控制它们的功能，并相应地影响细胞的命运。这些蛋白质间的相互作用以及GAPDH的翻译后修饰以一种类似两面神的分子方式介导其细胞毒性或细胞保护功能。在这篇综述中，我们讨论了该酶在细胞生理学中的功能特性及其可能参与人类病理过程的情况。在文章的最后部分，我们描述了可用于在某些病理状态下调节该酶功能的药物。
