两种无机牛骨在上颌窦提升术中的比较：一项采用临床、影像学和组织形态计量学分析的双侧对照研究。

Comparison of two anorganic bovine bone in maxillary sinus lift: a split-mouth study with clinical, radiographical, and histomorphometrical analysis.

作者信息

da Silva Heitor Fontes, Goulart Douglas Rangel, Sverzut Alexander Tadeu, Olate Sergio, de Moraes Márcio

机构信息

Division of Oral and Maxillofacial Surgery, Department of Oral Diagnosis, Piracicaba Dental School, Campinas State University Unicamp, Av. Limeira, 901, Areiao, Piracicaba, São Paulo, 13414-903, Brazil.

Dental School University of Goiás - UFG, Goiânia, Brazil.

出版信息

Int J Implant Dent. 2020 May 6;6(1):17. doi: 10.1186/s40729-020-00214-w.

BACKGROUND

Anorganic bovine bone (Bio-Oss®) has been extensively used for reconstruction of posterior area of maxilla in sinus lift procedure; however, a new graft material (Lumina-Bone Porous®), that has a different manufacturing process, has not been yet compared in clinical and histological terms. The manufacturing process of bovine bone graft is related to size and porosity of the particles, and this can change osteoconductive property of the material and bone formation. The use of Lumina-Porus® could improve bone formation, reduce the remaining particles of the biomaterial using a low-cost material. The aim of this research was to compare the clinical, radiological, and histomorphometrical results from maxillary sinus lift with two different anorganic bovine bone substitutes Bio-Oss® (control) and Lumina-Bone Porous® (test).

RESULTS

A split-mouth study was performed with 13 volunteers. The mean bone ridge height in the deepest portion of maxillary sinuses floor was 3.11 ± 0.83 mm in the Bio-Oss® and 2.38 ± 0.75 mm in the Lumina-Bone Porous®. After sinus lift, the Bio-Oss® group shows bone ridge height of 11.56 ± 2.03 mm and Lumina-Bone® of 10.62 ± 1.93 mm. The increase in alveolar bone height scores was significant between pre-augmentation and 6 months after SL in both groups (p < 0.001). No statistical significant difference in newly formed bone in the Bio-Oss® group (20.4 ± 5.4%), and Lumina-Bone Porous® (22.8 ± 8.5%) was histomorphological observed (p > 0.05). On the other hand, the residual graft particles showed significant difference between the Bio-Oss® group (19.9 ± 8.6%) and Lumina-Bone Porous® (14.6 ± 5.6%) (p < 0.05). The survival rate of dental implants for augmented area with Lumina Bone Porous® was 88.88%, while for Bio-Oss® group was 100%.

CONCLUSION

Both materials Bio-Oss® and Lumina-Bone Porous® can be used in the maxillary sinus floor augmentation with good predictability in clinical, radiographical, and histological point of view.

背景

无机牛骨（Bio-Oss®）已广泛用于上颌窦提升术中上颌后部区域的重建；然而，一种制造工艺不同的新型移植材料（Lumina-Bone Porous®）尚未在临床和组织学方面进行比较。牛骨移植材料的制造工艺与颗粒的大小和孔隙率有关，这会改变材料的骨传导性能和骨形成。使用Lumina-Porus®可以改善骨形成，使用低成本材料减少生物材料的残留颗粒。本研究的目的是比较使用两种不同的无机牛骨替代物Bio-Oss®（对照）和Lumina-Bone Porous®（试验）进行上颌窦提升的临床、放射学和组织形态计量学结果。

结果

对13名志愿者进行了一项双侧对照研究。上颌窦底最深部分的平均骨嵴高度在Bio-Oss®组为3.11±0.83毫米，在Lumina-Bone Porous®组为2.38±0.75毫米。上颌窦提升后，Bio-Oss®组的骨嵴高度为11.56±2.03毫米，Lumina-Bone®组为10.62±1.93毫米。两组在术前增强和上颌窦提升术后6个月之间牙槽骨高度评分的增加均具有统计学意义（p<0.001）。在组织形态学上，Bio-Oss®组（20.4±5.4%）和Lumina-Bone Porous®组（22.8±8.5%）新形成骨没有统计学显著差异（p>0.05）。另一方面，Bio-Oss®组（19.9±8.6%）和Lumina-Bone Porous®组（14.6±5.6%）的残留移植颗粒显示出显著差异（p<0.05）。使用Lumina Bone Porous®的种植体在上颌窦提升区域的存活率为88.88%，而Bio-Oss®组为100%。