Piotrowski Igor, Kulcenty Katarzyna, Suchorska Wiktoria
Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Garbary 15 Street, 61-866 Poznań, Poland.
Department of Electroradiology, University of Medical Sciences, Garbary 15 Street, 61-866 Poznań, Poland.
Rep Pract Oncol Radiother. 2020 May-Jun;25(3):422-427. doi: 10.1016/j.rpor.2020.04.004. Epub 2020 Apr 13.
Tumor-promoting inflammation is one of the hallmarks of cancer. It has been shown that cancer development is strongly influenced by both chronic and acute inflammation process. Progress in research on inflammation revealed a connection between inflammatory processes and neoplastic transformation, the progression of tumour, and the development of metastases and recurrences. Moreover, the tumour invasive procedures (both surgery and biopsy) affect the remaining tumour cells by increasing their survival, proliferation and migration. One of the concepts explaining this phenomena is an induction of a wound healing response. While in normal tissue it is necessary for tissue repair, in tumour tissue, induction of adaptive and innate immune response related to wound healing, stimulates tumour cell survival, angiogenesis and extravasation of circulating tumour cells. It has become evident that certain types of immune response and immune cells can promote tumour progression more than others. In this review, we focus on current knowledge on carcinogenesis and promotion of cancer growth induced by inflammatory processes.
肿瘤促进性炎症是癌症的标志之一。研究表明，癌症的发展受到慢性和急性炎症过程的强烈影响。炎症研究的进展揭示了炎症过程与肿瘤转化、肿瘤进展以及转移和复发的发展之间的联系。此外，肿瘤侵入性操作（手术和活检）通过提高剩余肿瘤细胞的存活率、增殖率和迁移率来影响这些细胞。解释这一现象的概念之一是诱导伤口愈合反应。虽然在正常组织中这对于组织修复是必要的，但在肿瘤组织中，与伤口愈合相关的适应性和先天性免疫反应的诱导会刺激肿瘤细胞存活、血管生成和循环肿瘤细胞的外渗。已经很明显，某些类型的免疫反应和免疫细胞比其他类型更能促进肿瘤进展。在这篇综述中，我们聚焦于炎症过程诱导癌症发生和促进癌症生长的现有知识。
