Hernandez-Baltazar Daniel, Nadella Rasajna, Mireya Zavala-Flores Laura, Rosas-Jarquin Christian de Jesús, Rovirosa-Hernandez María de Jesús, Villanueva-Olivo Arnulfo
CONACYT-Instituto de Neuroetologia, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
IIIT Srikakulam, Rajiv Gandhi University of Knowledge Technologies (RGUKT); International collaboration ID:1840; India.
Iran J Basic Med Sci. 2019 Jul;22(7):716-721. doi: 10.22038/ijbms.2019.33659.8025.
Parkinson's disease (PD) is characterized by motor and cognitive dysfunctions. The progressive degeneration of dopamine-producing neurons that are present in the (SNpc) has been the main focus of study and PD therapies since ages.
In this manuscript, a systematic revision of experimental and clinical evidence of PD-associated cell process was conducted.
Classically, the damage in the dopaminergic neuronal circuits of SNpc is favored by reactive oxidative/nitrosative stress, leading to cell death. Interestingly, the therapy for PD has only focused on avoiding the symptom progression but not in finding a complete reversion of the disease. Recent evidence suggests that the renin-angiotensin system imbalance and neuroinflammation are the main keys in the progression of experimental PD.
The progression of neurodegeneration in SNpc is due to the complex interaction of multiple processes. In this review, we analyzed the main contribution of four cellular processes and discussed in the perspective of novel experimental approaches.
帕金森病（PD）的特征在于运动和认知功能障碍。自多年来，存在于黑质致密部（SNpc）的多巴胺能神经元的进行性退化一直是研究和PD治疗的主要焦点。
在本手稿中，对与PD相关的细胞过程的实验和临床证据进行了系统修订。
传统上，SNpc多巴胺能神经元回路的损伤受反应性氧化/亚硝化应激的影响，导致细胞死亡。有趣的是，PD的治疗仅专注于避免症状进展，而不是寻找疾病的完全逆转。最近的证据表明，肾素-血管紧张素系统失衡和神经炎症是实验性PD进展的主要关键。
SNpc中神经退行性变的进展是由于多种过程的复杂相互作用。在本综述中，我们分析了四个细胞过程的主要贡献，并从新的实验方法角度进行了讨论。
