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利用水提取物抑制HaCaT细胞中诱导炎症的促炎细胞因子。

Inhibition of Proinflammatory Cytokines in -Induced Inflammation in HaCaT Cells by Using Aqueous Extract.

作者信息

Nguyen Anh Thu, Kim Ki-Young

机构信息

Graduate School of Biotechnology, Kyung Hee University, Giheung, Yongin-si, Gyeonggi-do 1732, Republic of Korea.

出版信息

Int J Inflam. 2020 Apr 21;2020:8063289. doi: 10.1155/2020/8063289. eCollection 2020.

DOI:10.1155/2020/8063289
PMID:32373312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7191358/
Abstract

Acne is an inflammatory skin disorder; although some anti-inflammatory medicines for treating acne are available in a market, they have considerable side effects; therefore, new treatment options are needed. In the present study, among the 16 aqueous extracts of plants collected from Jeju Island in Korea which are used to test anti-inflammatory activity, showed the strong decline of the proinflammatory cytokine expression against the inflammatory process caused by in Human HaCaT keratinocyte cells. downregulated the expression of 57% of COX-2, 41% of iNOS, and proinflammatory cytokines 29% of TNF-, 32% of IL-1, 21% of IL-6, and 35% of IL-8. Furthermore, inhibited NF-B and MAPK signaling cascades in keratinocytes that activated by toll-like receptor 2 (TLR-2) in response to . Given those results, is a potential agent to reduce the proinflammatory cytokine expression against -induced inflammation and might provide an alternative to the current medications.

摘要

痤疮是一种炎症性皮肤病；尽管市场上有一些用于治疗痤疮的抗炎药物，但它们有相当大的副作用；因此，需要新的治疗选择。在本研究中，从韩国济州岛采集的16种植物水提取物用于测试抗炎活性，其中一种提取物在人HaCaT角质形成细胞中对由[具体物质未提及]引起的炎症过程显示出促炎细胞因子表达的显著下降。[提取物名称未提及]下调了57%的COX-2、41%的iNOS的表达以及促炎细胞因子29%的TNF-α、32%的IL-1、21%的IL-6和35%的IL-8的表达。此外，[提取物名称未提及]抑制了角质形成细胞中由Toll样受体2（TLR-2）响应[具体物质未提及]而激活的NF-κB和MAPK信号级联反应。鉴于这些结果，[提取物名称未提及]是一种潜在的药物，可减少针对[具体物质未提及]诱导的炎症的促炎细胞因子表达，并可能为当前药物提供替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/4b878d9c5fed/IJI2020-8063289.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/b67da600c9cb/IJI2020-8063289.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/94214d72c9fe/IJI2020-8063289.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/da2db322e2ac/IJI2020-8063289.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/cac9c31bf360/IJI2020-8063289.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/80ae192f88e9/IJI2020-8063289.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/4b878d9c5fed/IJI2020-8063289.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/b67da600c9cb/IJI2020-8063289.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/94214d72c9fe/IJI2020-8063289.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/da2db322e2ac/IJI2020-8063289.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/cac9c31bf360/IJI2020-8063289.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/80ae192f88e9/IJI2020-8063289.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/7191358/4b878d9c5fed/IJI2020-8063289.006.jpg

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