Inhibition of Proinflammatory Cytokines in -Induced Inflammation in HaCaT Cells by Using Aqueous Extract.

Acne is an inflammatory skin disorder; although some anti-inflammatory medicines for treating acne are available in a market, they have considerable side effects; therefore, new treatment options are needed. In the present study, among the 16 aqueous extracts of plants collected from Jeju Island in Korea which are used to test anti-inflammatory activity, showed the strong decline of the proinflammatory cytokine expression against the inflammatory process caused by in Human HaCaT keratinocyte cells. downregulated the expression of 57% of COX-2, 41% of iNOS, and proinflammatory cytokines 29% of TNF-, 32% of IL-1, 21% of IL-6, and 35% of IL-8. Furthermore, inhibited NF-B and MAPK signaling cascades in keratinocytes that activated by toll-like receptor 2 (TLR-2) in response to . Given those results, is a potential agent to reduce the proinflammatory cytokine expression against -induced inflammation and might provide an alternative to the current medications.