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雷公藤甲素通过刺激ERK1/2促进角质形成细胞增殖。

Promotion of Keratinocyte Proliferation by Tracheloside through ERK1/2 Stimulation.

作者信息

Kim JaeGoo, Shin Yu-Kyong, Kim Ki-Young

机构信息

Graduate School of Biotechnology, Kyung Hee University, Yongin-si, Gyeonggi-do, Republic of Korea.

College of Life Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2018 Jul 26;2018:4580627. doi: 10.1155/2018/4580627. eCollection 2018.

DOI:10.1155/2018/4580627
PMID:30147732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6083535/
Abstract

Cell migration and proliferation are important for proper wound healing after skin injury. Recent studies have shown that compounds from plants could promote cell migration and proliferation. Tracheloside, which is a plant lignan, has been found to promote the growth of HaCaT cells over 40% compared to other compounds tested based on a cell proliferation assay. An scratch assay confirmed the healing activity of tracheloside (more than 2-fold increased healing activity after 24 hours of treatment compared with the control) and revealed that this activity is better than that of allantoin (1.2-fold increased after 24 hours of treatment compared with the control), a positive control. With western blot results, wound healing with tracheloside occurred through the phosphorylation of ERK1/2. Therefore, tracheloside is a good candidate to promote wound healing and could be developed as a therapeutic agent for wound treatment or used as a leading compound with higher activity.

摘要

细胞迁移和增殖对于皮肤损伤后的正常伤口愈合至关重要。最近的研究表明，植物中的化合物可以促进细胞迁移和增殖。基于细胞增殖试验，与其他测试化合物相比，植物木脂素雷公藤苷已被发现可促进HaCaT细胞生长超过40%。划痕试验证实了雷公藤苷的愈合活性（与对照组相比，处理24小时后愈合活性增加了2倍以上），并表明该活性优于阳性对照尿囊素（与对照组相比，处理24小时后增加了1.2倍）。根据蛋白质印迹结果，雷公藤苷诱导的伤口愈合是通过ERK1/2的磷酸化实现的。因此，雷公藤苷是促进伤口愈合的良好候选物，可开发为伤口治疗的治疗剂或用作具有更高活性的先导化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/018fd3284180/ECAM2018-4580627.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/983f531de318/ECAM2018-4580627.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/07bd9ec500fb/ECAM2018-4580627.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/4e38cf5b137f/ECAM2018-4580627.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/018fd3284180/ECAM2018-4580627.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/983f531de318/ECAM2018-4580627.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/07bd9ec500fb/ECAM2018-4580627.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/4e38cf5b137f/ECAM2018-4580627.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db56/6083535/018fd3284180/ECAM2018-4580627.004.jpg

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