Department of Epidemiology and Health Statistics, the School of Public Health of Qingdao University, People's Republic of China.
J Glob Health. 2020 Jun;10(1):010417. doi: 10.7189/jogh.10.010417.
We conducted a meta-analysis to explore the relationship between exposure to air pollution and the risk of cognitive impairment of longitudinal cohort studies.
PubMed, Web of Science and Wan Fang databases were searched for relevant articles of longitudinal cohort studies published between January 1950 and September 2019. The pooled relative ratio (RR) and 95% confidence interval (CI) were calculated using the random effect model.
Ten articles involving 519 247 cases among 12 523 553 participants were included in this meta-analysis. The pooled RR of cognitive impairment per 5 μg/m increments in exposure to particulate matter ≤2.5 μm (PM) was 1.08 (95% CI = 1.03, 1.13; = 82.2%; <0.001). No association was found between nitrogen dioxide/nitrogen oxide (NO/NO) and ozone (O) and cognitive impairment. For PM exposure, in subgroup analysis, the above-mentioned significant positive association was found among studies conducted in population (RR 1.05; 95% CI = 1.01,1.09; = 57.4%; = 0.016), in North America (RR = 1.13; 95% CI = 1.01,1.26; = 86.7%; <0.001) and with follow-up duration >10 years (RR = 1.10; 95% CI = 1.03,1.17; = 86.3%; <0.001).
This meta-analysis suggests that exposure to PM might increase the risk of cognitive impairment.
我们进行了一项荟萃分析，以探讨暴露于空气污染与纵向队列研究中认知障碍风险之间的关系。
检索了 1950 年 1 月至 2019 年 9 月期间发表的有关纵向队列研究的相关文章，使用 PubMed、Web of Science 和万方数据库。使用随机效应模型计算合并相对比（RR）和 95%置信区间（CI）。
纳入了 10 项研究，涉及 12523553 名参与者中的 519247 例病例。暴露于颗粒物≤2.5μm（PM）每增加 5μg/m，认知障碍的合并 RR 为 1.08（95%CI=1.03，1.13； = 82.2%；<0.001）。二氧化氮/氮氧化物（NO/NO）和臭氧（O）与认知障碍之间没有关联。对于 PM 暴露，在亚组分析中，在人群中进行的研究中发现了上述显著的正相关（RR = 1.05；95%CI=1.01，1.09； = 57.4%； = 0.016），在北美（RR = 1.13；95%CI=1.01，1.26； = 86.7%；<0.001）和随访时间>10 年（RR = 1.10；95%CI=1.03，1.17； = 86.3%；<0.001）。
这项荟萃分析表明，暴露于 PM 可能会增加认知障碍的风险。
