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弥漫性大 B 细胞淋巴瘤中复发富集患者系列中探索的突变动态和免疫逃逸。

Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series.

机构信息

Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

Norwegian Cancer Genomics Consortium, Oslo, Norway.

出版信息

Blood Adv. 2020 May 12;4(9):1859-1866. doi: 10.1182/bloodadvances.2019001325.

DOI:10.1182/bloodadvances.2019001325
PMID:32374878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7218413/
Abstract

Diagnostic and relapse diffuse large B-cell lymphoma (DLBCL) biopsies reveal increased mutational burden/loss of heterozygosity in . Serially sampled tumor biopsies provide insight into therapeutic targets and evolutionary divergence in relapsed/refractory DLBCL.

摘要

诊断和复发弥漫性大 B 细胞淋巴瘤（DLBCL）活检显示. 突变负担增加/杂合性丢失。连续取样的肿瘤活检为复发/难治性 DLBCL 的治疗靶点和进化分歧提供了深入了解。

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