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Genomic and transcriptomic characterization reveals B-cell hyperactivation and immune evasion in hepatitis B virus-associated diffuse large B-cell lymphoma.

作者信息

Qin Wei, Wang Nan, Shi Qing, Sun Rui, Zheng Zhong, Fu Di, Dong Lei, Li Chen, Zhang Yifang, Xu Pengpeng, Cheng Shu, Qian Ying, Feng Yan, Wang Li, Zhao Weili

机构信息

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Pathology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Clin Transl Med. 2023 Jun;13(6):e1293. doi: 10.1002/ctm2.1293.

DOI:10.1002/ctm2.1293
PMID:37288581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10248824/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/b6b17a0c9063/CTM2-13-e1293-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/0d424acf0978/CTM2-13-e1293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/70505c1caa88/CTM2-13-e1293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/1dfd5b6e9202/CTM2-13-e1293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/b6b17a0c9063/CTM2-13-e1293-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/0d424acf0978/CTM2-13-e1293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/70505c1caa88/CTM2-13-e1293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/1dfd5b6e9202/CTM2-13-e1293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ef/10248824/b6b17a0c9063/CTM2-13-e1293-g004.jpg

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Genomic and transcriptomic characterization reveals B-cell hyperactivation and immune evasion in hepatitis B virus-associated diffuse large B-cell lymphoma.基因组和转录组特征揭示了乙型肝炎病毒相关弥漫性大B细胞淋巴瘤中的B细胞过度激活和免疫逃逸。
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2
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本文引用的文献

1
Clinicopathological and prognostic features of hepatitis B virus-associated diffuse large B-cell lymphoma: a single-center retrospective study in China.乙型肝炎病毒相关弥漫性大B细胞淋巴瘤的临床病理及预后特征:一项中国单中心回顾性研究
Infect Agent Cancer. 2021 Aug 17;16(1):57. doi: 10.1186/s13027-021-00396-x.
2
Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma.乙型肝炎病毒相关弥漫性大 B 细胞淋巴瘤的遗传景观。
Blood. 2018 Jun 14;131(24):2670-2681. doi: 10.1182/blood-2017-11-817601. Epub 2018 Mar 15.
3
Hepatitis B virus and risk of non-Hodgkin lymphoma: An updated meta-analysis of 58 studies.
乙型肝炎病毒与非霍奇金淋巴瘤风险:58项研究的最新荟萃分析
J Viral Hepat. 2018 Aug;25(8):894-903. doi: 10.1111/jvh.12892. Epub 2018 Apr 2.
4
Regulatory T cells in cancer immunotherapy.癌症免疫治疗中的调节性T细胞。
Cell Res. 2017 Jan;27(1):109-118. doi: 10.1038/cr.2016.151. Epub 2016 Dec 20.
5
Mechanisms of Action of Lenalidomide in B-Cell Non-Hodgkin Lymphoma.来那度胺在B细胞非霍奇金淋巴瘤中的作用机制
J Clin Oncol. 2015 Sep 1;33(25):2803-11. doi: 10.1200/JCO.2014.59.5363. Epub 2015 Jul 20.
6
Dynamics of B cells in germinal centres.生发中心B细胞的动态变化
Nat Rev Immunol. 2015 Mar;15(3):137-48. doi: 10.1038/nri3804. Epub 2015 Feb 6.
7
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.胸腺髓质中的上皮细胞和树突状细胞通过 CD27-CD70 途径促进 CD4+Foxp3+调节性 T 细胞的发育。
J Exp Med. 2013 Apr 8;210(4):715-28. doi: 10.1084/jem.20112061. Epub 2013 Apr 1.
8
Clinical consequences of defects in B-cell development.B 细胞发育缺陷的临床后果。
J Allergy Clin Immunol. 2010 Apr;125(4):778-87. doi: 10.1016/j.jaci.2010.02.018.
9
Germinal centres: role in B-cell physiology and malignancy.生发中心:在B细胞生理学和恶性肿瘤中的作用
Nat Rev Immunol. 2008 Jan;8(1):22-33. doi: 10.1038/nri2217.
10
Aberrant expression and reverse signalling of CD70 on malignant B cells.恶性B细胞上CD70的异常表达与反向信号传导。
Br J Haematol. 1999 Aug;106(2):491-503. doi: 10.1046/j.1365-2141.1999.01573.x.