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找出差异：淀粉样纤维中的功能与毒性。

Spot the Difference: Function versus Toxicity in Amyloid Fibrils.

机构信息

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

出版信息

Trends Biochem Sci. 2020 Aug;45(8):635-636. doi: 10.1016/j.tibs.2020.04.007. Epub 2020 May 3.

DOI:10.1016/j.tibs.2020.04.007
PMID:32376150
Abstract

In a recent study, Hervas et al. extracted Orb2 fibrils, that are involved in long-term memory formation, from Drosophila brains, characterised their function, and determined their structure using cryo-electron microscopy (cryo-EM). The fibrils show a remarkable resemblance to amyloid β (Aβ) fibrils associated with Alzheimer's disease, highlighting the subtle difference between functional and dysfunctional amyloid.

摘要

在最近的一项研究中，Hervas 等人从果蝇大脑中提取了参与长期记忆形成的 Orb2 纤维，使用冷冻电镜（cryo-EM）对其功能进行了表征，并确定了其结构。这些纤维与阿尔茨海默病相关的淀粉样β（Aβ）纤维具有惊人的相似性，突出了功能和非功能淀粉样蛋白之间的细微差异。

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2
Amyloid structures: much more than just a cross-β fold.淀粉样结构：远不止一种β-折叠。
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Microbial functional amyloids serve diverse purposes for structure, adhesion and defence.微生物功能性淀粉样蛋白在结构、黏附及防御方面发挥着多种作用。
鸡平滑肌肌联蛋白的非特异性淀粉样聚集：体外研究。
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Toward high-throughput oligomer detection and classification for early-stage aggregation of amyloidogenic protein.面向淀粉样蛋白早期聚集的高通量寡聚体检测与分类
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Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins.超越核心：侧翼区域在淀粉样生成肽和蛋白质聚集过程中的作用
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