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Imatinib might constitute a treatment option for lung involvement in COVID-19.

作者信息

Bernal-Bello David, Jaenes-Barrios Beatriz, Morales-Ortega Alejandro, Ruiz-Giardin José Manuel, García-Bermúdez Virginia, Frutos-Pérez Begoña, Farfán-Sedano Ana Isabel, de Ancos-Aracil Cristina, Bermejo Fernando, García-Gil Mario, Zapatero-Gaviria Antonio, San Martín-López Juan Víctor

机构信息

Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Madrid, Spain..

Castilla La Nueva Primary Health Care Center, Madrid, Spain..

出版信息

Autoimmun Rev. 2020 Jul;19(7):102565. doi: 10.1016/j.autrev.2020.102565. Epub 2020 May 3.

DOI:10.1016/j.autrev.2020.102565
PMID:32376403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7252139/
Abstract
摘要

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Corona (COVID-19) time musings: Our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning.新冠(COVID-19)时期的思考:我们在新冠病毒致病机制、诊断、治疗及疫苗研发计划中的参与情况
Autoimmun Rev. 2020 Jun;19(6):102538. doi: 10.1016/j.autrev.2020.102538. Epub 2020 Apr 5.
2
The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease.细胞因子(包括白细胞介素 6)在 COVID-19 诱导性肺炎和巨噬细胞活化综合征样疾病中的作用。
Autoimmun Rev. 2020 Jun;19(6):102537. doi: 10.1016/j.autrev.2020.102537. Epub 2020 Apr 3.
3
COVID-19: consider cytokine storm syndromes and immunosuppression.2019冠状病毒病:考虑细胞因子风暴综合征和免疫抑制。
Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16.
4
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.2019 冠状病毒病(COVID-19)疫情的起源、传播和临床治疗——现状更新。
Mil Med Res. 2020 Mar 13;7(1):11. doi: 10.1186/s40779-020-00240-0.
5
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).羟氯喹治疗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2)的体外抗病毒活性和优化剂量设计预测。
Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237.
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J Med Virol. 2020 Jun;92(6):556-563. doi: 10.1002/jmv.25729. Epub 2020 Mar 12.
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Baricitinib as potential treatment for 2019-nCoV acute respiratory disease.巴瑞替尼作为2019新型冠状病毒急性呼吸道疾病的潜在治疗方法。
Lancet. 2020 Feb 15;395(10223):e30-e31. doi: 10.1016/S0140-6736(20)30304-4. Epub 2020 Feb 4.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学:对病毒起源和受体结合的影响。
Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
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Imatinib stimulates prostaglandin E and attenuates cytokine release via EP4 receptor activation.伊马替尼通过激活EP4受体刺激前列腺素E并减弱细胞因子释放。
J Allergy Clin Immunol. 2019 Feb;143(2):794-797.e10. doi: 10.1016/j.jaci.2018.09.030. Epub 2018 Oct 16.
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Clin Rheumatol. 2018 Jun;37(6):1729-1735. doi: 10.1007/s10067-018-4018-1. Epub 2018 Mar 21.