Dept. of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
Dept. of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
Int J Pharm. 2020 Jun 15;583:119398. doi: 10.1016/j.ijpharm.2020.119398. Epub 2020 May 4.
Over the last three decades, research in the field of phospholipid nanocarriers as tools to improve dermal and transdermal drug delivery has grown substantially. In particular, liposomes have been the target of studies aimed at reformulating vesicles with a greater ability to deliver drugs trans-dermally. A number of additives with varied physicochemical properties have been combined with traditional components of liposomes. These novel modification processes have produced new classes of vesicles with the potential to enhance the treatment of both dermatological disorders and systemic pathologies. Development of the first deformable and elastic phospholipid vesicles has highlighted the key role of vesicle composition in promoting release of vesicle content into and through the skin. This paper discusses the key vesicle properties and mechanisms of delivery by which newly developed phospholipid vesicles can improve percutaneous drug delivery.
在过去的三十年中，作为改善皮肤和经皮药物递送工具的磷脂纳米载体领域的研究取得了实质性的进展。特别是脂质体一直是研究的目标，旨在用具有更大经皮递药能力的囊泡来改造脂质体。许多具有不同物理化学性质的添加剂与传统的脂质体成分结合在一起。这些新的修饰过程产生了具有增强治疗皮肤疾病和全身疾病潜力的新型囊泡。首例可变形和弹性磷脂囊泡的开发突出了囊泡组成在促进囊泡内容物释放到皮肤中和通过皮肤的关键作用。本文讨论了新开发的磷脂囊泡通过改善经皮药物递送来提高药物递送的关键囊泡性质和机制。
