Center for MicroElectroMechanical Systems (CMEMS-UMINHO), University of Minho, Azurém Campus, 4800-058, Guimarães, Portugal.
Clínica do Dragão, Espregueira-Mendes Sports Centre, FIFA Medical Centre of Excellence, Porto, Portugal.
Ann Biomed Eng. 2020 Jun;48(6):1616-1639. doi: 10.1007/s10439-020-02515-y. Epub 2020 May 6.
The purpose of this systematic review is to analyze characteristics and methodologies utilized in bioheat transfer models of human skin to provide state-of-the-art knowledge on the topic. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. PubMed, EMBASE and Web of Science databases were searched up to May 30th, 2019 for bioheat transfer models focusing on direct contact between skin and temperature (heat and/or cold) source. Ten studies were included. A 16-item checklist was used to assess their methodological quality. Four studies analyzed healthy skin and six included pathological conditions. All determined skin's thermal behavior, and studies including pathological conditions also analyzed burn damage. Studies did not present a wide variety of mathematical formulation, emphasizing on modelling equations of well-established models from the literature, such as the Pennes' bioheat transfer equation, and the Henriques and Moritz model to quantify skin damage. Reporting of modelling characteristics and formulation of the computational models is not standardized and there is shortage of implementation of validation procedures, hindering representative conclusions. The lack of validation procedures led to low methodological quality. However, all studies provided strategies and parameters as starting points for future developments in this research area.
本系统评价的目的是分析人体皮肤生物传热模型的特点和方法学，为该主题提供最新知识。本综述按照系统评价和荟萃分析的首选报告项目进行。截至 2019 年 5 月 30 日，在 PubMed、EMBASE 和 Web of Science 数据库中搜索了聚焦于皮肤与温度（热和/或冷）源直接接触的生物传热模型的研究。共纳入 10 项研究。使用 16 项检查表评估其方法学质量。四项研究分析了健康皮肤，六项研究包括了病理状况。所有研究都确定了皮肤的热行为，包括病理状况的研究还分析了烧伤损伤。研究没有提出广泛的数学公式，而是强调了对文献中已有模型的建模方程的分析，如 Pennes 生物传热方程和 Henriques 和 Moritz 模型，以量化皮肤损伤。模型特征和计算模型的公式化报告没有标准化，验证程序的实施也不足，阻碍了有代表性的结论。缺乏验证程序导致方法学质量较低。然而，所有研究都为该研究领域的未来发展提供了策略和参数作为起点。
