Pharmacy of College, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China.
Shenzhen Traditional Chinese Medicine Hospital, No. 1 Fuhua Road, Shenzhen, Guangdong, 518033, PR China.
J Pharmacol Sci. 2020 Jul;143(3):165-175. doi: 10.1016/j.jphs.2020.04.007. Epub 2020 Apr 26.
yeyachun and danshen exist as Chinese patent medicine, Xuemai Tong, and are clearly effective at alleviating liver fibrosis (LF). Previous studies have indicated that triterpenoids from yeyachun (EFT), and phenolic acids from danshen (SMP) are effective in the treatment of LF. The regulation of intestinal flora is an effective method for treating LF. The aim of this study was to investigate the effect of a mixture of EFT and SMP on carbon tetrachloride (CCl) induced LF. Our results showed the mixture significantly decreased liver damage and fibrosis index, and maintained liver tissue composition, compared to the model group. Moreover, the imbalance of symptoms of intestinal flora was improved. The mixture also caused changes to metabolites of gut flora. Furthermore, the expression of CD68 in liver tissues from the treated groups was significantly decreased when compared to the model group. However, no significant difference was observed from microstructure of gut tissues and LPS concentrations in the serum between mixture treated mice and model mice. This study suggests that the mixture of EFT and SMP had a significant effect on CCl induced LF, and the mechanism of this action, at least in part, involved the regulation of intestinal flora and their metabolites.
叶下珠和丹参作为中药，血府逐瘀丸，明确能减轻肝纤维化（LF）。先前的研究表明，叶下珠中的三萜（EFT）和丹参中的酚酸（SMP）对 LF 的治疗有效。调节肠道菌群是治疗 LF 的有效方法。本研究旨在探讨 EFT 和 SMP 混合物对四氯化碳（CCl）诱导的 LF 的影响。我们的结果表明，与模型组相比，该混合物显著降低了肝损伤和纤维化指数，并维持了肝组织成分。此外，改善了肠道菌群失衡的症状。该混合物还导致了肠道菌群代谢物的变化。此外，与模型组相比，治疗组肝组织中 CD68 的表达明显降低。然而，混合物处理的小鼠和模型小鼠的肠道组织微观结构和血清中 LPS 浓度没有明显差异。本研究表明，EFT 和 SMP 的混合物对 CCl 诱导的 LF 有显著影响，其作用机制至少部分涉及肠道菌群及其代谢物的调节。
