葛根多糖对小鼠肠道微生物群的影响。
Effects of polysaccharide from Pueraria lobata on gut microbiota in mice.
作者信息
Chen Rong, Liu Bo, Wang Xiaoyang, Chen Kai, Zhang Keyu, Zhang Lifang, Fei Chenzhong, Wang Chunmei, Yingchun Liu, Xue Feiqun, Gu Feng, Wang Mi
机构信息
Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
出版信息
Int J Biol Macromol. 2020 May 5. doi: 10.1016/j.ijbiomac.2020.04.201.
Polysaccharide was derived from Pueraria lobata (PPL) which was considered as one of the traditional Chinese medicinal and edible herbs. In the present study, PPL was administered in equal doses (12.5 mg/kg) to both normal mice and antibiotic-associated diarrhea (AAD) mice for two weeks, and was evaluated in terms of body weight, organ indices, gut structure, gut microbiota and short chain fatty acids. The results showed that normal mice treated with PPL not only reduced the isovaleric acid concentration (P < 0.05), but also significantly increased the abundance of beneficial bacteria, involving Oscillospira and Anaerotruncus (P < 0.05). In addition, PPL could relieve colonic pathological changes and gut microbiota dysbiosis caused by AAD. It indicated that PPL was a potential functional food ingredient by modulating gut microbiota.
多糖源自葛根（PPL），葛根被视为传统的药食两用草药之一。在本研究中，以等量剂量（12.5毫克/千克）给正常小鼠和抗生素相关性腹泻（AAD）小鼠施用PPL两周，并从体重、器官指数、肠道结构、肠道微生物群和短链脂肪酸方面进行评估。结果表明，用PPL处理的正常小鼠不仅降低了异戊酸浓度（P<0.05），而且显著增加了有益细菌的丰度，包括颤螺菌属和厌氧短杆菌属（P<0.05）。此外，PPL可以缓解由AAD引起的结肠病理变化和肠道微生物群失调。这表明PPL是一种通过调节肠道微生物群发挥作用的潜在功能性食品成分。
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