Sampath Udeni Gunathilake Thennakoon M, Ching Yern Chee, Chuah Cheng Hock, Rahman Noorsaadah Abd, Liou Nai-Shang
Advanced Materials Center, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Advanced Materials Center, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Int J Biol Macromol. 2020 May 7;158:670-688. doi: 10.1016/j.ijbiomac.2020.05.010.
The limitations of existing drug delivery systems (DDS) such as non-specific bio-distribution and poor selectivity have led to the exploration of a variety of carrier platforms to facilitate highly desirable and efficient drug delivery. Stimuli-responsive DDS are one of the most versatile and innovative approach to steer the compounds to the intended sites by exploiting their responsiveness to a range of various triggers. Preparation of stimuli-responsive DDS using celluloses and their derivatives offer a remarkable advantage over conventional polymer materials. In this review, we highlight on state-of-art progress in developing cellulose/cellulose hybrid stimuli-responsive DDS, which covers the preparation techniques, physicochemical properties, basic principles and, mechanisms of stimuli effect on drug release from various types of cellulose based carriers, through recent innovative investigations. Attention has been paid to endogenous stimuli (pH, temperature, redox gradient and ionic-strength) responsive DDS and exogenous stimuli (light, magnetic field and electric field) responsive DDS, where the cellulose-based materials have been extensively employed. Furthermore, the current challenges and future prospects of these DDS are also discussed at the end.
现有药物递送系统（DDS）存在诸如非特异性生物分布和选择性差等局限性，这促使人们探索各种载体平台，以实现高效且理想的药物递送。刺激响应性DDS是最具通用性和创新性的方法之一，它通过利用化合物对一系列不同触发因素的响应，将化合物导向目标部位。使用纤维素及其衍生物制备刺激响应性DDS比传统聚合物材料具有显著优势。在本综述中，我们重点介绍了开发纤维素/纤维素杂化刺激响应性DDS的最新进展，这些进展涵盖了制备技术、物理化学性质、基本原理以及通过近期创新性研究得出的各种基于纤维素的载体对药物释放的刺激作用机制。我们关注了内源性刺激（pH、温度、氧化还原梯度和离子强度）响应性DDS和外源性刺激（光、磁场和电场）响应性DDS，其中基于纤维素的材料已被广泛应用。此外，在文末还讨论了这些DDS当前面临的挑战和未来前景。
