Department of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, VU University medical centre, 1081 HV, Amsterdam, The Netherlands; Department of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands.
Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands.
J Infect. 2020 Aug;81(2):190-204. doi: 10.1016/j.jinf.2020.05.002. Epub 2020 May 7.
The intestinal microbiota develops in early infancy and is essential for health status early and later in life. In this review we focus on the effect of prenatal and intrapartum maternally administered antibiotics on the infant intestinal microbiota.
A systematic literature search was conducted in PubMed and EMBASE. All studies reporting effect on diversity or microbiota profiles were included.
A total of 4.030 records were encountered. A total of 24 articles were included in the final analysis. Infants from mothers exposed to antibiotics during delivery showed a decreased microbial diversity compared to non-exposed infants. The microbiota of infants exposed to antibiotics was characterised by a decreased abundance of Bacteriodetes and Bifidobacteria, with a concurrent increase of Proteobacteria. These effects were most pronounced in term vaginally born infants.
Maternal administration of antibiotics seems to have profound effects on the infant gut microbiota colonisation. Interpretation of microbiota aberrations in specific populations, such as preterm and caesarean born infants, is complicated by multiple confounding factors and by lack of high quality studies and high heterogeneity in study design. Further research is needed to investigate the potential short- and long-term clinical consequences of these microbial alterations.
肠道微生物群在婴儿早期发育，对生命早期和后期的健康状况至关重要。在这篇综述中，我们重点关注产前和分娩期母亲使用抗生素对婴儿肠道微生物群的影响。
在 PubMed 和 EMBASE 中进行了系统的文献检索。纳入了所有报告多样性或微生物群谱变化影响的研究。
共遇到 4030 条记录。共有 24 篇文章纳入最终分析。与未暴露的婴儿相比，分娩时暴露于抗生素的母亲所生婴儿的微生物多样性降低。暴露于抗生素的婴儿的微生物群特征是厚壁菌门和双歧杆菌的丰度降低，同时变形菌门的丰度增加。这些影响在足月阴道分娩的婴儿中最为明显。
母亲使用抗生素似乎对婴儿肠道微生物群定植有深远影响。在特定人群（如早产儿和剖宫产婴儿）中，对微生物群异常的解释受到多种混杂因素以及缺乏高质量研究和研究设计高度异质性的影响。需要进一步研究这些微生物改变的潜在短期和长期临床后果。
