Slavokhotova Anna A, Rogozhin Eugene A
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, Russia.
Front Plant Sci. 2020 Apr 23;11:465. doi: 10.3389/fpls.2020.00465. eCollection 2020.
Plant immunity represents a sophisticated system, including both basal and inducible mechanisms, to prevent pathogen infection. Antimicrobial peptides (AMPs) are among the innate immunity components playing a key role in effective and rapid response against various pathogens. This review is devoted to a small family of defense peptides called α-hairpinins. The general characters of the family, as well as the individual features of each member, including biological activities, structures of precursor proteins, and spatial structures, are described. Possible applications of α-hairpinin peptides in drug design are discussed.
植物免疫是一个复杂的系统，包括基础免疫和诱导免疫机制，用于防止病原体感染。抗菌肽（AMPs）是先天免疫的组成部分，在对各种病原体的有效和快速反应中发挥关键作用。本综述聚焦于一类名为α-发夹素的防御肽小家族。文中描述了该家族的一般特征以及每个成员的个体特征，包括生物活性、前体蛋白结构和空间结构。还讨论了α-发夹素肽在药物设计中的潜在应用。
