Shen Tianjiao, Bimali Milan, Faramawi Mohammed, Orloff Mohammed S
Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Front Nutr. 2020 Apr 21;7:47. doi: 10.3389/fnut.2020.00047. eCollection 2020.
Chronic obstructive pulmonary disease (COPD) comprising of emphysema and chronic bronchitis are the most common chronic respiratory diseases that impart a huge economic and clinical burden. Factors other than smoking and air pollutants can cause inflammation and emphysematous changes in the lung airspaces or alveoli have been understudied. Using a cross-sectional study design, we assessed the association of dark green vegetables, vitamin K and Vitamin A with emphysema status among adults at U.S. These nutrients have a role in lung biology. A complete case NHANES data ( = 17,681) was used. After adjusting for modifiable and non-modifiable confounders, consumption of recommended amounts of vitamin K was associated with 39% decrease in odds (Odds Ratio: 0.61; 95% CI: 0.40-0.92, -val: 0.02) of emphysema. Similarly consumption of recommended amounts vitamin A dose was associated with 33% decrease in odds (Odds Ratio: 0.67; 95% CI: 0.44-1.00, -val: 0.05) of emphysema. Vitamin K shows an inverse association suggesting that it may be important in slowing the emphysematous process. Vitamin A is important in maintaining the anti-inflammatory process. Together vitamin K and vitamin A are important in the lung health.
慢性阻塞性肺疾病（COPD）包括肺气肿和慢性支气管炎，是最常见的慢性呼吸道疾病，会带来巨大的经济和临床负担。除吸烟和空气污染物外，其他可导致肺部气腔或肺泡发生炎症和肺气肿变化的因素尚未得到充分研究。我们采用横断面研究设计，评估了深绿色蔬菜、维生素K和维生素A与美国成年人肺气肿状况之间的关联。这些营养素在肺部生物学中发挥作用。我们使用了完整的美国国家健康和营养检查调查（NHANES）数据（n = 17,681）。在对可改变和不可改变的混杂因素进行调整后，摄入推荐量的维生素K与肺气肿患病几率降低39%相关（比值比：0.61；95%置信区间：0.40 - 0.92，P值：0.02）。同样，摄入推荐量的维生素A剂量与肺气肿患病几率降低33%相关（比值比：0.67；95%置信区间：0.44 - 1.00，P值：0.05）。维生素K呈现出负相关，表明其在减缓肺气肿进程中可能很重要。维生素A在维持抗炎过程中很重要。维生素K和维生素A共同对肺部健康很重要。
