Hashimoto Kaho, Chinen Takumi, Kitagawa Daiju
Department of Physiological Chemistry, Graduate School of Pharmaceutical Science, The University of Tokyo, Bunkyo, Tokyo, Japan.
Mol Cell Oncol. 2020 Apr 3;7(3):1743899. doi: 10.1080/23723556.2020.1743899. eCollection 2020.
Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells. However, the detailed mechanisms describing how spindle bipolarity is established without centrosomes are not completely understood. We have recently demonstrated that in acentrosomal human cells, nuclear mitotic apparatus protein (NuMA) assemblies-mediated microtubule asters and EG5 promote spindle bipolarization in early mitosis.
中心体对于细胞分裂并非绝对必要；在卵母细胞和去除中心体的体细胞中可以形成无中心体的双极纺锤体。然而，关于在没有中心体的情况下纺锤体双极性如何建立的详细机制尚未完全了解。我们最近证明，在无中心体的人类细胞中，核有丝分裂装置蛋白（NuMA）组装介导的微管星状体和驱动蛋白Eg5在有丝分裂早期促进纺锤体双极化。
