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Invest Ophthalmol Vis Sci. 2020 May 11;61(5):5. doi: 10.1167/iovs.61.5.5.
We investigated and characterized the patterns of meridional anisotropies in newly diagnosed refractive amblyopes using pattern onset-offset visual evoked potentials (POVEPs) and psychophysical grating acuity (GA).
Twenty-five refractive amblyopes were recruited and compared with non-amblyopic controls from our previous study. Monocular POVEPs were recorded in response to sinewave 4 cycles per degree (cpd) grating stimuli oriented along each individual participants' principal astigmatic meridians, which were approximately horizontal (meridian 1) and vertical (meridian 2). Binocular POVEPs in response to the same stimuli, but oriented at 45°, 90°, 135°, and 180°, were recorded. Psychophysical GAs were assessed along the same meridians using a two-alternative non-forced-choice technique. The C3 amplitudes and peak latencies of the POVEPs and GAs were compared across meridians for both groups (refractive amblyopes and controls) using linear mixed models (monocular) and ANOVA (binocular), and post hoc analysis was conducted to determine if meridional anisotropies in this cohort of amblyopes were related to low (≤1.50 diopters [D]), moderate (1.75-2.75 D) and high (≥3.00 D) astigmatism.
In the newly diagnosed refractive amblyopes, there were no significant meridional anisotropies across all outcome measures, but the post hoc analysis demonstrated that C3 amplitude was significantly higher in those with low (P = 0.02) and moderate (P = 0.004) astigmatism compared to those with high astigmatism. Refractive amblyopes had poorer GA and C3 amplitudes compared to controls by approximately two lines on the logMAR chart (monocular: P = 0.013; binocular: P = 0.014) and approximately 6 µV (monocular: P = 0.009; binocular: P = 0.027), respectively.
Deleterious effects of high astigmatism was evident in newly diagnosed refractive amblyopes, but the neural deficits do not seem to be orientation-specific for the stimulus parameters investigated.
我们通过视觉诱发电位（POVEP）和心理物理光栅视力（GA）研究并描述新诊断的屈光性弱视患者的子午线各向异性模式。
从我们之前的研究中招募了 25 名屈光性弱视患者，并将其与非弱视对照组进行比较。使用正弦波 4 个周期/度（cpd）光栅刺激记录单眼 POVEP，这些刺激沿每个参与者的主要散光子午线排列，大致为水平（子午线 1）和垂直（子午线 2）。记录双眼 POVEP 对相同刺激的反应，但方向为 45°、90°、135°和 180°。使用二选一非强制选择技术，在同一子午线评估心理物理 GA。使用线性混合模型（单眼）和 ANOVA（双眼）比较两组（屈光性弱视患者和对照组）在各子午线的 POVEP 和 GA 的 C3 幅度和峰潜伏期，并进行事后分析，以确定该组弱视患者的子午线各向异性是否与低（≤1.50 屈光度 [D]）、中（1.75-2.75 D）和高（≥3.00 D）散光相关。
在新诊断的屈光性弱视患者中，所有结果测量均无明显的子午线各向异性，但事后分析表明，与高度散光相比，低（P = 0.02）和中度（P = 0.004）散光患者的 C3 幅度明显更高。屈光性弱视患者的 GA 和 C3 幅度均明显低于对照组，单眼约为 2 行（logMAR 图表：P = 0.013），双眼约为 6 µV（logMAR 图表：P = 0.009）。
在新诊断的屈光性弱视患者中，高度散光的有害影响是明显的，但神经缺陷似乎不是针对研究刺激参数的特定方向。
