Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Thorac Cancer. 2020 Jul;11(7):1885-1890. doi: 10.1111/1759-7714.13474. Epub 2020 May 12.
The five-year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis. In this study, we aimed to evaluate the predictive value of EDNRB on LUAD.
Survival analyses was performed to assess the correlation between EDNRB expression and survival of LUAD patients from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) datasets. Gene set enrichment analysis (GSEA) was conducted to illustrate possible biological functions of EDNRB. Laboratory methods were used to verify the function of EDNRB in LUAD.
The TCGA results showed that a low expression of EDNRB was found in LUAD patients which led to poor outcome and worse survival, compared with the high expression in GSEA results which suggested that expression of EDNRB might be associated with regulation of the ERK pathway. Laboratory results suggested that EDNRB could inhibit the proliferation and migration of LUAD H1299 cells.
EDNRB is a potential prognostic marker for LUAD patients and might exert its functions by regulating the ERK pathway in LUAD.
肺腺癌患者（LUAD）的五年生存率非常低，预测生存的方法是 LUAD 治疗的一大障碍。内皮素受体 B（EDNRB）基因与肿瘤发生有关。本研究旨在评估 EDNRB 对 LUAD 的预测价值。
从癌症基因组图谱（TCGA）和中国脑胶质瘤基因组图谱（CGGA）数据集进行生存分析，评估 EDNRB 表达与 LUAD 患者生存的相关性。进行基因集富集分析（GSEA）以说明 EDNRB 的可能生物学功能。使用实验室方法验证 EDNRB 在 LUAD 中的功能。
TCGA 结果表明，与 GSEA 结果中的高表达相比，LUAD 患者的 EDNRB 低表达导致不良结局和较差的生存，这表明 EDNRB 的表达可能与 ERK 通路的调节有关。实验室结果表明，EDNRB 可抑制 LUAD H1299 细胞的增殖和迁移。
EDNRB 是 LUAD 患者的潜在预后标志物，可能通过调节 LUAD 中的 ERK 通路发挥其功能。
