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How can proton pump inhibitors damage central and peripheral nervous systems?

作者信息

Makunts Tigran, Abagyan Ruben

机构信息

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.

出版信息

Neural Regen Res. 2020 Nov;15(11):2041-2042. doi: 10.4103/1673-5374.282252.

DOI:10.4103/1673-5374.282252
PMID:32394957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7716020/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a293/7716020/14d531a64ad1/NRR-15-2041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a293/7716020/14d531a64ad1/NRR-15-2041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a293/7716020/14d531a64ad1/NRR-15-2041-g001.jpg

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2
Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory.质子泵抑制剂的使用与广泛的神经系统不良事件相关，包括听力、视力和记忆力受损。
Sci Rep. 2019 Nov 21;9(1):17280. doi: 10.1038/s41598-019-53622-3.
3
Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis.
甲硝唑相关神经系统不良事件的频率及危险因素分析。
J Gen Intern Med. 2024 May;39(6):912-920. doi: 10.1007/s11606-023-08566-w. Epub 2023 Dec 13.
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Association between Proton Pump Inhibitor Use and Parkinson's Disease in a Korean Population.韩国人群中质子泵抑制剂的使用与帕金森病之间的关联。
Pharmaceuticals (Basel). 2022 Mar 9;15(3):327. doi: 10.3390/ph15030327.
质子泵抑制剂上市后安全性数据分析显示其致肾损伤、电解质异常和肾结石的倾向性增加。
Sci Rep. 2019 Feb 19;9(1):2282. doi: 10.1038/s41598-019-39335-7.
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Front Neurol. 2019 Jan 8;9:1142. doi: 10.3389/fneur.2018.01142. eCollection 2018.
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