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没食子酸酯抑制 IgE 介导的肥大细胞活化和小鼠被动皮肤过敏反应。

Eckol from Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice.

机构信息

Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea.

National Marine Biodiversity Institute of Korea, 75, Jangsan-ro 101 gil, Janghang-eup, Seocheon 33662, Korea.

出版信息

Nutrients. 2020 May 9;12(5):1361. doi: 10.3390/nu12051361.

DOI:10.3390/nu12051361
PMID:32397556
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7284712/
Abstract

Eckol, a precursor compound belonging to the dibenzo-1,4-dioxin class of phlorotannins, is a phloroglucinol derivative that exerts various activities. In the present study, we investigated the antiallergic effects of eckol isolated from the marine brown algae, using immunoglobulin E (IgE)/bovine serum albumin (BSA)-stimulated mouse bone marrow-derived cultured mast cells (BMCMC) and a mouse model of anaphylaxis. Eckol inhibited IgE/BSA-induced BMCMC degranulation by reducing β-hexosaminidase release. A flow cytometric analysis revealed that eckol decreases FcεRI expression on cell surface and IgE binding to the FcεRI in BMCMC. Moreover, eckol suppressed the production of the cytokines, interleukin (IL)-4, IL-5, IL-6, and IL-13 and the chemokine, thymus activation-regulated chemokine (TARC) by downregulating, IκB-α degradation and NF-κB nuclear translocation. Furthermore, it attenuated the passive cutaneous anaphylactic reaction induced by IgE/BSA-stimulation in the ear of BALB/c mice. These results suggest that eckol is a potential therapeutic candidate for the prevention and treatment of allergic disorders.

摘要

表儿茶素，一种属于二苯并-1,4-二氧杂芘类的菲类单宁前体化合物，是一种邻苯三酚衍生物，具有多种活性。在本研究中，我们使用免疫球蛋白 E（IgE）/牛血清白蛋白（BSA）刺激的小鼠骨髓来源培养肥大细胞（BMCMC）和过敏小鼠模型，研究了从海洋褐藻中分离出的表儿茶素的抗过敏作用。表儿茶素通过减少β-己糖胺酶释放来抑制 IgE/BSA 诱导的 BMCMC 脱颗粒。流式细胞术分析表明，表儿茶素降低了细胞表面 FcεRI 的表达和 IgE 与 BMCMC 中 FcεRI 的结合。此外，表儿茶素通过下调 IκB-α 降解和 NF-κB 核易位，抑制细胞因子白细胞介素（IL）-4、IL-5、IL-6 和 IL-13 以及趋化因子胸腺激活调节趋化因子（TARC）的产生。此外，它还可减轻 IgE/BSA 刺激引起的 BALB/c 小鼠耳部被动皮肤过敏反应。这些结果表明，表儿茶素是预防和治疗过敏疾病的潜在治疗候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/74fb541f839b/nutrients-12-01361-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/dc99523d4336/nutrients-12-01361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/1791ad504783/nutrients-12-01361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/46482eb9c225/nutrients-12-01361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/61ff159dd451/nutrients-12-01361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/a6dcedc2521e/nutrients-12-01361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/78c87db22dbc/nutrients-12-01361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/74fb541f839b/nutrients-12-01361-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/dc99523d4336/nutrients-12-01361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/1791ad504783/nutrients-12-01361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/46482eb9c225/nutrients-12-01361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/61ff159dd451/nutrients-12-01361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/a6dcedc2521e/nutrients-12-01361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/78c87db22dbc/nutrients-12-01361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c9/7284712/74fb541f839b/nutrients-12-01361-g007.jpg

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