Blakley B R
Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada.
Drug Nutr Interact. 1988;5(4):395-401.
Female Swiss mice were exposed to zinc chloride (0 to 500 ug/mL) or copper sulfate (0 to 200 ug/mL) in their drinking water for 15 weeks. After 3 weeks of the exposure period, the mice were administered urethan (1.5 mg/g) intraperitoneally. Urethan-induced pulmonary adenoma formation was evaluated 12 weeks later. Zinc exposure increased the number of adenomas produced but reduced the mean tumor diameter in the intermediate treatment groups, 50 and 200 ug/mL. Exposure to copper had no effect on tumor size or on tumor number. Weight gains in the mice were not affected by copper or zinc treatment, although a dose-dependent reduction in water consumption was observed with copper. Water consumption in mice exposed to zinc was elevated in one treatment group (50 ug/mL). Urethan-induced sleeping times, which reflect the rate of urethan excretion, were prolonged by zinc exposure but were unaffected by copper exposure. This finding suggests that zinc exposure impairs the elimination of urethan and enhances its carcinogenic activity, which is manifested by increased tumor formation.
将雌性瑞士小鼠的饮用水中加入氯化锌（0至500微克/毫升）或硫酸铜（0至200微克/毫升），持续15周。在暴露期3周后，给小鼠腹腔注射乌拉坦（1.5毫克/克）。12周后评估乌拉坦诱导的肺腺瘤形成情况。在中间治疗组（50和200微克/毫升）中，锌暴露增加了腺瘤产生的数量，但减小了平均肿瘤直径。铜暴露对肿瘤大小或肿瘤数量没有影响。小鼠的体重增加不受铜或锌处理的影响，尽管观察到铜处理后饮水量呈剂量依赖性减少。在一个锌暴露处理组（50微克/毫升）中，小鼠的饮水量增加。反映乌拉坦排泄速率的乌拉坦诱导睡眠时间因锌暴露而延长，但不受铜暴露的影响。这一发现表明，锌暴露会损害乌拉坦的消除并增强其致癌活性，这表现为肿瘤形成增加。
