Blakley B R
Drug Nutr Interact. 1987;5(2):97-102.
Female Swiss were exposed to sodium selenite (3 micrograms/ml selenium content) and sodium arsenate (80 micrograms/ml arsenic content) in the drinking water individually or in combination on alternate days for 15 weeks. Comparable water consumption was observed in all individual or combined metal-exposure groups. After 3 weeks of metal exposure, the mice were administered urethan (1.5 mg/g) intraperitoneally. Pulmonary adenoma formation was evaluated 12 weeks later. Arsenic exposure reduced the tumor incidence (P = 0.0046) and tumor size (P less than 0.0001). Selenium exposure did not alter the tumor incidence but caused a reduction in tumor size (P = 0.022). No selenium-arsenic interactions associated with tumor size or number were observed. Urethan-induced sleeping times were unaffected by exposure to selenium (P = 0.832) or arsenic (P = 0.42), although combined metal exposure reduced the duration of urethan-induced sleep (P = 0.029) as compared to the individual metal exposures. This metal-metal interaction, which appeared to enhance the rate of urethan elimination as indicated by the reduced sleeping time, did not influence adenoma formation significantly.
将雌性瑞士小鼠的饮用水中隔日单独或联合添加亚硒酸钠（硒含量为3微克/毫升）和砷酸钠（砷含量为80微克/毫升），持续15周。在所有单独或联合金属暴露组中观察到可比的饮水量。金属暴露3周后，给小鼠腹腔注射乌拉坦（1.5毫克/克）。12周后评估肺腺瘤形成情况。砷暴露降低了肿瘤发生率（P = 0.0046）和肿瘤大小（P < 0.0001）。硒暴露未改变肿瘤发生率，但导致肿瘤大小减小（P = 0.022）。未观察到与肿瘤大小或数量相关的硒 - 砷相互作用。乌拉坦诱导的睡眠时间不受硒暴露（P = 0.832）或砷暴露（P = 0.42）的影响，尽管与单独金属暴露相比，联合金属暴露缩短了乌拉坦诱导的睡眠时间（P = 0.029）。这种金属 - 金属相互作用似乎加快了乌拉坦的消除速度，表现为睡眠时间缩短，但对腺瘤形成没有显著影响。
