Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou 510260, China.
Guangzhou Zoo, Guangzhou 510230, China.
Viruses. 2019 Oct 24;11(11):979. doi: 10.3390/v11110979.
Pangolins are endangered animals in urgent need of protection. Identifying and cataloguing the viruses carried by pangolins is a logical approach to evaluate the range of potential pathogens and help with conservation. This study provides insight into viral communities of Malayan Pangolins () as well as the molecular epidemiology of dominant pathogenic viruses between Malayan Pangolin and other hosts. A total of 62,508 assembled contigs were constructed, and a BLAST search revealed 3600 ones (≥300 nt) were related to viral sequences, of which 68 contigs had a high level of sequence similarity to known viruses, while dominant viruses were the Sendai virus and Coronavirus. This is the first report on the viral diversity of pangolins, expanding our understanding of the virome in endangered species, and providing insight into the overall diversity of viruses that may be capable of directly or indirectly crossing over into other mammals.
穿山甲是濒危动物，急需保护。鉴定和编目穿山甲所携带的病毒是评估潜在病原体范围并有助于保护的合理方法。本研究深入了解了马来亚穿山甲的病毒群落以及马来亚穿山甲与其他宿主之间主要致病病毒的分子流行病学。总共构建了 62508 个组装的连续体，BLAST 搜索显示有 3600 个（≥300nt）与病毒序列相关，其中 68 个连续体与已知病毒具有高度相似性，而主要病毒是仙台病毒和冠状病毒。这是穿山甲病毒多样性的首次报道，扩展了我们对濒危物种病毒组的理解，并深入了解了可能直接或间接跨越到其他哺乳动物的病毒的整体多样性。
